Entrectinib
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Catalog numberB1324-5
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Price:
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Size5 mg
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Alternative_name(Z)-N-(5-(3,5-difluorobenzyl)-1H-indazol-3(2H)-ylidene)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide
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DescriptionEntrectinib is an inhibitor of TrkA (IC₅₀ = 1.7 nM), TrkB (IC₅₀ = 0.1 nM), and TrkC (IC₅₀ = 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC₅₀ = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC₅₀ = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations, and inhibits ALK‐dependent signaling
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CAS Number1108743-60-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₃₁H₃₄F₂N₆O₂
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Molecular Weight560.64
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Cell PermeableYes
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Purity≥97% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA tyrosine kinase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID25141092
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SMILESN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
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InChiInChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
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InChi KeyHAYYBYPASCDWEQ-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameEntrectinib
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Alternative nameEntrectinib
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