flt-3-Ligand, murine recombinant
-
Catalog number
4086-10
-
Price
Please ask
-
Size
10 ug
-
-
Synonyms
Fms-related tyrosine kinase 3 ligand
-
Alternative_names
Fms-related tyrosine kinase 3 ligand, Short name=Flt3 ligand, Short name=Flt3L, SL cytokine
-
Description
A member of a small family of growth factors that stimulate the proliferation of hematopoietic cells
-
Recombinant
Yes
-
Source
E. coli
-
Purity by SDS PAGE
≥98%
-
Assay
SDS-PAGE
-
Purity
≥98%
-
Biological activity
Determined by the dose dependent proliferation of mouse AML5 cells
-
Results
5-8 ng/ml
-
Molecular Weight
16.4 kDa
-
Storage Temp
-20°C
-
Shipping
Gel pack
-
Shelf Life
12 months
-
Appearance
Lyophilized protein
-
Physical form description
Sterile filtered and lyophilized with no additives.
-
Reconstitution Instructions
Reconstitute in H₂O to a concentration of 0.1 – 1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
-
Background Information
Flt3-Ligand belongs to a small group of growth factors that regulate proliferation of early hematopoietic cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant form is the transmembrane which is biologically active on the cell surface. The proteolytically cleaved transmembrane isoform generates a soluble form, which is also biologically active. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand alone cannot stimulate proliferation, but synergizes well with other CSFs and interleukins to induce growth and differentiation. Recombinant murine flt3-Ligand is a 16.4 kDa protein containing 144 amino acid residues.
-
Handling
Centrifuge the vial prior to opening.
-
Usage
For Research Use Only! Not to be used in humans
-
-
Additional description
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
-
Additional source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
MIR1302-3, MIR509-3, MIR7-3, PIRC13, PIRC11, PIRC12, PIRC14
-
Short name
flt-3-Ligand, murine recombinant
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
Alternative name
flt-3-Ligand, murine Rec.
-
Alternative technique
rec
-
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 1302-3
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 509-3
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 7-3
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
Gene info
Gene info
Gene info
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
