A-803467 is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Na(v1.8). Na(v1.8) is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50's for rat and human Na(v1.8) are 140 nM and 8.0 nM respectively.
Is it cell-permeable?
≥98% by TLC
Is this a salt?
Protect from air and light
Maximum time for storage
DMSO (~30 mg/ml) or EtOH (~ 5 mg/ml)
For cells, cell lines and tissues in culture till half confluency.
A-803467 for activation
A-803467 to measure cellular activation