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CD-14, mouse recombinant

CD-14, mouse recombinant is available 1 time from Biovision labs

4938-10 | CD-14, mouse recombinant size: 10 ug | 525.92 USD

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Synonyms CD14, Cluster of differentiation 14, mouse CD14, CD14, h-CD14, rm-CD14, recombinant mouse CD14, recombinant CD14, CD14
Alternative_names CD14, Cluster of differentiation 14, Human CD14, CD14, h-CD14, rh-CD14, recombinant human CD14, recombinant CD14, CD14, Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
Description A high affinity receptor for complexes of LPS and LPS binding protein
Recombinant Yes
Source CHO cells
Purity by SDS-PAGE 90-95%
Assay SDS-PAGE
Biological activity Inhibits binding of LPS to CD14. Up to 5µg/ml mouse CD14 inhibit binding of FITC-LPS (0.5µg/ml) to mouse CD14+ CHO transfectants
Molecular Weight 50.0 kDa
Storage Temp. -20°C
Shipping Gel pack
Shelf Life 12 months
Appearance Lyophilized protein
Physical form description Lyophilized from a concentrated protein solution (1 mg/ml) containing PBS, pH 7.2
Reconstitution Instructions Reconstitute in 10 µl of ultra-pure distilled water. This solution can then be diluted into other aqueous buffers and stored at –20°C or –70°C for future use.
Background Information CD14 acts as a receptor for endotoxin (LPS), is expressed strongly on monocy¬tes, macrophages and weekly at surface of neutrophiles. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor LPS-LBP (lipopolysaccharide binding protein)-complexes. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids, acts at physiological concentrations as LPS agonist and has at higher concentrations an antagonizing effect in cell activation. The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wild type CD14 is the 50 kDa protein. This is a His-tagged protein.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Test Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name Mus musculus
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetCD-14
Short name CD-14, mouse recombinant
Technique Recombinant, Mouse
Host mouse
Species Mouse
Alternative name CD-14, mouse recombinant
Alternative technique rec
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