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Mouse Anti Rat SHANK3 Monoclonal IgG2b Clone S69 46

Mouse Anti Rat SHANK3 Monoclonal IgG2b Clone S69 46 is available 19 times from Stressmark antibodies labs

SMC-336D-PCP | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 466.50 USD

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SMC-336S | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 12 µg | 59.05 USD

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SMC-336D-P594 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 475.94 USD

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SMC-336D-A488 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 467.68 USD

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SMC-336D-FITC | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 458.23 USD

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SMC-336D-A633 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 467.68 USD

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SMC-336D-BI | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 462.95 USD

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SMC-336D-A700 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 467.68 USD

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SMC-336D | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 410.99 USD

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SMC-336D-APC | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 466.50 USD

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SMC-336D-A390 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 468.86 USD

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SMC-336D-STR | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 465.31 USD

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SMC-336D-ALP | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 460.59 USD

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SMC-336D-A655 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 467.68 USD

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SMC-336D-RPE | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 464.13 USD

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SMC-336D-A594 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 467.68 USD

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SMC-336D-A680 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 467.68 USD

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SMC-336D-HRP | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 453.50 USD

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SMC-336D-A565 | Mouse Anti-Rat SHANK3 Monoclonal IgG2b, Clone S69-46 size: 100 µg | 467.68 USD

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Clone S69-46
Immunogen Synthetic peptide amino acids 840-857 of rat Shank3
Antibody's category Monoclonal Antibodies
Antibody's other name AI841104 antibody, DEL22q13.3 antibody, KIAA1650 antibody, Proline rich synapse associated protein 2 antibody, Proline-rich synapse-associated protein 2 antibody, ProSAP2 antibody, PSAP2 antibody, SH3 and multiple ankyrin repeat domains 3 antibody, SH3 and multiple ankyrin repeat domains protein 3 antibody SH3/ankyrin domain gene 3 antibody, SHAN3_HUMAN antibody, Shank postsynaptic density protein antibody, Shank3 antibody, Shank3b antibody, SPANK 2 antibody, SPANK2 antibody
Raised in Mouse
Antibody's target SHANK3
Primary research fields Neuroscience, Cell Structure, Post-Synaptic Markers
Brandname None
Antibodies' applications WB, IHC, ICC/IF, IP, AM
Antibody's reactivity Human, Mouse, Rat
Antibody's dilutions WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purity Protein G Purified
Antibody buffer for storage PBS pH7.4, 50% glycerol, 0.09% sodium azide
Antibody's concentration 1 mg/ml
Antibody's specificity Detects ~190kDa. No cross-reactivity against Shank1 or Shank2.
Storage recommendations -20ºC
Shipping recommendations Blue Ice or 4ºC
Antibody certificate of analysis 1 µg/ml of SMC-336 was sufficient for detection of Shank3 in 10 µg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Antibody in cell Cytoplasm , Cell Junction , Synapse , Postsynaptic Cell Membrane , Postsynaptic Density
Tissue specificity See included datasheet or contact our support service
Scientific context Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3).
Bibliography 1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856. 2. Schuetz G., et al. (2004) JCB. 167(5): 645-952. 3. Durand C.M., et al. (2007) Nature Genetics. 39: 25-27.
Released date 13-Apr-2010
Tested applications To be tested
Tested reactivity To be tested
NCBI number NP_067708.1
Gene number 59312
Protein number Q9JLU4
Antibody's datasheet Contact our support service
Representative figure linkmore | details | see here
Representative figure legend Immunohistochemistry analysis using Mouse Anti-SHANK3 Monoclonal Antibody, Clone S69-46 (SMC-336). Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-SHANK3 Monoclonal Antibody (SMC-336) at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Early stages of filaggrin-like and dermal staining. Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK3 Monoclonal Antibody, Clone S69-46 (SMC-336). Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-SHANK3 Monoclonal Antibody (SMC-336) at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Borderline positive. Western Blot analysis of Rat brain membrane lysate showing detection of SHANK3 protein using Mouse Anti-SHANK3 Monoclonal Antibody, Clone S69-46 (SMC-336). Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-SHANK3 Monoclonal Antibody (SMC-336) at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. Mouse Anti-SHANK3 Antibody [S69-46] used in Immunohistochemistry (IHC) on Mouse backskin (SMC-336) Mouse Anti-SHANK3 Antibody [S69-46] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human HaCaT cells (SMC-336) Mouse Anti-SHANK3 Antibody [S69-46] used in Western Blot (WB) on Rat brain membrane lysate (SMC-336)
Warning information Non-hazardous
Country of production Canada
Total weight (kg) 1.4
Stock availability In Stock
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Additional isotype IgG2b
About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Test Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name Mus musculus,Rattus norvegicus
Gene targetSHANK3 Monoclonal IgG2b S69-46
Short name Mouse Anti- SHANK3 Monoclonal IgG2b, Clone S69-46
Technique Mouse, anti
Host mouse
Isotype IgG2b
Species Rat
Alternative name Mouse antibody to-Rat SHANK3 monoclonal IgG2b, clonality S69-46
Alternative technique antibodies
Clone name S69-46
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Mouse Anti Rat SHANK3 Monoclonal IgG2b Clone S69 46
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  • SHANK3
  • Monoclonal
  • IgG2b
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