Lysosomal Cytotoxicity Dual Staining Kit (Cell-Based)

• Catalog number
  K458-50
• Price
  Please ask
• Size
  50 assays

• Summary
  • Detection method- Flow cytometry and Fluorescence Microscopy • Species reactivity- Mammalian • Applications - Measurement of Lysosomal cytotoxicity - Screening compounds affecting lysosomal function
• Detection Method
  Flow Cytometry (FL1/FL2)
• Species Reactivity
  Mammalian
• Applications
  • Measurement of lysosomal cytotoxicity. • Staining for lysosome cytotoxicity and cell death. • Screening for compounds that affect lysosomal function
• Sample Type
  Suspension or adherent cell cultures
• Features Benefits
  Measurement of lysosomal cytotoxicity.
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Lysosomes are membrane-bound organelles important for various cellular processes. They contain hydrolytic enzymes utilized in the metabolism of some biomolecules. The extracellular cargo (e.g. nutrients, toxins) binds to the cell membrane and is subsequently transported into membrane-bound endosomes for further degradation by lysosomes while intracellular components are transported to lysosomes through autophagy. Lysosomal dysfunction is associated with many human conditions such as aging and neurodegenerative disease. BioVision has developed the Lysosomal Cytotoxicity Dual Staining Kit (cell-based) which contains two probes; membrane permeable, selective Lysosomal Stain and Cell Death Marker. We also include a Positive Control Reagent, which increases lysosome activity and staining, thus serves as an experimental control. This easy-to-use, non-radioactive kit allows studying the regulation of lysosome and cytotoxicity at the cellular level by using Fluorescence Microscopy and Flow Cytometry in cultured cells.
• Data Sheet Link
• Additional description
  For cells, cell lines and tissues in culture till half confluency.
• Test
  The duality of this product lies in it's dual specificity to the gene, pH or protein. Mainly in phosphorylation by specific phosphatases.

• Gene target
  Lysosomal   Cytotoxicity   Staining   Kit   Based  
• Short name
  Lysosomal Cytotoxicity Staining Kit ( -Based)
• Label
  dual
• Alternative name
  Lysosomal Cytotoxicity Dual coloring reagent (cellular-Based)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
• Tissue
  cell

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