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PRL-1 (2-173) N termnal GST tag - Active Enzyme

PRL-1 (2-173) N termnal GST tag - Active Enzyme is available 1 time from Nordc labs

X1657E | PRL-1 (2-173) N termnal GST tag - Active Enzyme size: 10 μg | 507.88 USD

Catalog number X1657E
Supplier nordc
Price 507.88 USD
Size 10 μg
1. Gene info
Identity 9445
Gene PRL
Long gene name prolactin
GenBank acession
  • D00411
Locus 6p22.3
Discovery year 1986-01-01
Entrez gene record 5617
RefSeq identity
  • NM_000948
Classification
  • Neuropeptides
  • Growth hormone family
Havana BLAST/BLAT OTTHUMG00000016111
2. Gene info
Identity 18923
Gene KRTAP13-2
Long gene name keratin associated protein 13-2
Synonyms
  • KAP13-2
GenBank acession
  • AP001708
Locus 21q22.11
Discovery year 2003-02-21
Entrez gene record 337959
Pubmed identfication
  • 12359730
Classification
  • Keratin associated proteins
Havana BLAST/BLAT OTTHUMG00000057793
3. Gene info
Identity 17279
Gene OPRPN
Long gene name opiorphin prepropeptide
Synonyms gene
  • PROL1
Synonyms gene name
  • proline rich 1
  • proline rich, lacrimal 1
Synonyms
  • BPLP
  • PRL1
GenBank acession
  • S83198
Locus 4q13.3
Discovery year 2001-12-04
Entrez gene record 58503
Pubmed identfication
  • 8670737
  • 17101991
RefSeq identity
  • NM_021225
Havana BLAST/BLAT OTTHUMG00000160845
4. Gene info
Identity 7064
Gene MGST3
Long gene name microsomal glutathione S-transferase 3
Synonyms
  • GST-III
Synonyms name
  • microsomal glutathione S-transferase III
  • microsomal GST-3
  • microsomal GST-III
GenBank acession
  • AF026977
Locus 1q24.1
Discovery year 1997-10-16
Entrez gene record 4259
Pubmed identfication
  • 9278457
RefSeq identity
  • NM_004528
Classification
  • Microsomal glutathione S-transferases
Havana BLAST/BLAT OTTHUMG00000034627
Category Proteins & Peptides
Long description The product of the PRL-1 gene (alternate gene names PTP4A1 Synonyms:ÊDKFZp779M0721, hPTPCAAX1) is a protein tyrosine phosphatase also known as phosphatase of regenerating liver, Protein tyrosine phosphatase type IVA, member 1, PTPCAAX1 or Hypothetical protein DKFZp779M0721. Protein tyrosine phosphatases play important roles in the regulation of cell growth, development, and differentiation. PRL-1 is one of the most interesting immediate early growth response genes in regenerating liver. The gene encodes a novel 20-kDa nuclear protein tyrosine phosphatase. Other than the signature sequence for PTPases, PRL-1 is not homologous to either the dual specificity PTPases (cdc25 and MKP-1) or monospecific PTPases. PRL-1 is elevated throughout the major proliferative phase of liver regeneration when hepatocytes and nonparenchymal cells in the liver are rapidly proliferating. PR-1 is also expressed at high levels in other proliferating cells including tumor cell lines such as hepatomas. PRL-1-transfected cells showed altered growth characteristics, including a faster doubling time, growth to a greater saturation density, altered morphology, and evidence of anchorage-independent growth. Overexpression of human PRL-1 in epithelial cells results in tumor formation in_x000B_nude mice.
Antibody come from Synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho Thr386 of human MEK1
Other description Provided in HEPES (pH 7.5) solution containing 150 mM NaCl, 100 µg per ml BSA and 50% glycerol .
Clone not specified
Antigen-antibody binding interaction PRL-1 (2-173) N termnal GST tag - Active Enzyme
Antibody is raised in E.coli
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
Antibody's suited for Antibody should be used at a 1:1000 dilution to provide for 10 miniblots in Western blotting and dot blots. Antibody detects only phosphorylated protein and does not detect non-phosphorylated protein as shown by the lack of ability of a non-phospho peptide to block the antibody activity. Optimal concentration may be evaluated by serial dilutions.
Storage -20ºC
Relevant references 1. Adams, J.P. and Sweatt, J.D. 'Molecular psychology: Roles for the ERK MAP kinase cascade in memory,' Annu. Rev. Pharmacol. Toxicol. 42, 135-163 (2002). _x000B__x000B_2. Ahn, N.G. 'The MAP kinase cascade. Discovery of a new signal transduction pathway,' Mol. Cell Biochem. 127-128, 201-209 (1993). _x000B__x000B_3. Ahn, N.G., et al. 'Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin,' J. Neurochem. 59, 147-156 (1992). _x000B__x000B_4. Crews, C.M., et al. 'The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product,' Science 258, 478-480 (1992). _x000B__x000B_5. Mansour, S.J., et al. 'Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis.' J. Biochem. (Tokyo) 116, 304-314 (1994). _x000B__x000B_6. Park, S.H., et al. 'Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms,' Science 299, 1061-1064 (2003)._x000B__x000B_7. Chong H, Vikis HG, Guan KL (2003) Mechanisms of regulating the Raf kinase family. Cellular Signalling 15:463- 469._x000B__x000B_8. Kyriakis JM, Brautigan DL, Ingebritsen TS, Avruch J (1991) pp54 Microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. J Biol Chem 266:10043-10046._x000B__x000B_9. Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG (1991) Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophos- phorylation on both tyrosine and threonine residues: Implications for their mechanism of activation. Proc Natl Acad Sci USA 88:6142-6146.
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Description Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
Gene targetPRL-1 2-173 termnal GST tag Active
Short name PRL-1 (2-173) N termnal GST tag - Active Enzyme
Technique Enzyme
Isotype N/A
Label unlabeled
Alternative name PRL-1 (2-173) N termnal GST detection labelled - functionnal Enzyme
Alternative technique enzymes
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PRL-1 (2-173) N termnal GST tag - Active Enzyme | Technique
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • PRL-1
  • 2-173
  • termnal
  • GST
  • tag
  • Active
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