Cell-permeable. A potent inhibitor of Fms-like tyrosine kinase 3 (FLT3) kinase, PDGFRβ and c-Kit (IC50’s 95-122 ng/ml). It inhibits FLT3 phosphorylation, downstream signaling and tumor growth in vitro and in animal models.
White to off-white solid
Is this a salt?
Is it cell-permeable?
≥98% by HPLC
DMSO (~ 25 mg/ml) or EtOH (~ 25 mg/ml)
Maximum time for storage
Protect from air and moisture
For cells, cell lines and tissues in culture till half confluency.
Tandutinib for activation
Tandutinib to measure cellular activation