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Sphingosine Kinase

Sphingosine Kinase is available 8 times from Nordc labs

X1708E | Sphingosine Kinase 1 (Full Length) with N-Terminal HIS tag - Active Enzyme size: 10 μg | 507.88 USD

Catalog number X1708E
Supplier nordc
Price 507.88 USD
Size 10 μg
Long description Sphingosine Kinase 1 (Sphk1) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
Antibody come from Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a cytoskeletal preparation of OTN-11 ovarian carcinoma cells and SP2/0-Ag14 mouse myeloma cells.
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Antigen-antibody binding interaction Sphingosine Kinase 1 (Full Length) with N-Terminal HIS tag - Active Enzyme
Antibody is raised in Sf9 cells
Antibody's reacts with Human
Application Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Antibody's suited for Antibody can be used for immunohistochemistry on frozen or paraffin-embedded tissue, immunocytochemistry, immunoblotting (1:100-1:1000) and flow cytometry (1:100-1:200). Frozen sections require fixation in methanol. Paraffin-embedded sections require pretreatment with 0.1% pronase/0.1% trypsin in PBS or 0.5% pepsin in 0.01N HCl. Optimal concentration should be evaluated by serial dilutions.
Storage -80ºC
Relevant references 1. Ramaekers, F., et al. (1990). Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas, Am J Pathol 136, 641-55._x000B__x000B_2. van Niekerk, C. C., et al. (1991). Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues, J Pathol 165, 145-52._x000B__x000B_3. van Niekerk, C. C., et al. (1991). Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas, Am J Pathol 138, 455- 63._x000B__x000B_4. van de Molengraft, F. J., et al. (1993). OV-TL 12/30 (keratin 7 antibody) is a marker of_x000B_glandular differentiation in lung cancer, Histopathology 22, 35-8._x000B__x000B_5. van Niekerk, C. C., et al. (1997). Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies, Cancer Detect Prev 21, 247-57._x000B__x000B_6. Torenbeek, R., et al. (1998). Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma, Histopathology 32, 20-7.
Description Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
Conjugation histidine
Gene targetSphingosine Kinase Full Length with HIS tag Active
Short name Sphingosine Kinase 1 (Full Length) with N-Terminal HIS tag - Active Enzyme
Technique Enzyme
Isotype N/A
Alternative name Sphingosine phosphorylation catalyst 1 (complete Length) including N-Terminal histidine detection labelled - functionnal Enzyme
Alternative technique enzymes
1. Gene info
Identity 4806
Gene HAL
Long gene name histidine ammonia-lyase
Synonyms gene
  • HIS
Locus 12q23.1
Discovery year 1988-08-31
Entrez gene record 3034
Havana BLAST/BLAT OTTHUMG00000170354

X1875B | Sphingosine Kinase 1 antibody Long Form antibody Rat - Blocking Peptide size: 50 μg | 200.29 USD

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X1878B | Sphingosine Kinase 1 antibody Mouse - Blocking Peptide size: 50 μg | 200.29 USD

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X1632B | Sphingosine Kinase 1 Blocking peptide size: 50 μg | 200.29 USD

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X1850E | Sphingosine Kinase 1a (mouse recombinant antibody N-terminal His tag) - Active Enzyme size: 10 μg | 507.88 USD

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X1709E | Sphingosine Kinase 2 (N Terminal HIS Tag) - Active Enzyme size: 10 μg | 507.88 USD

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X1881B | Sphingosine Kinase 2 antibody Long Form antibody Human - Blocking Peptide size: 50 μg | 200.29 USD

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X1840E | Sphingosine Kinase 2 antibody Long Form N Terminal HIS Tag - Active Enzyme size: 10 μg | 507.88 USD

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Category Proteins & Peptides
Clone not specified
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Label unlabeled
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Sphingosine Kinase 1 (Full Length) with N-Terminal HIS tag -
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • Sphingosine
  • Kinase
  • Full
  • Length
  • with
  • HIS
  • tag
  • Active
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