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Sirtuin 1 (193-741) - Active Enzyme

Sirtuin 1 (193-741) - Active Enzyme is available 1 time from Nordc labs

X2037E | Sirtuin 1 (193-741) - Active Enzyme size: 100 μg | 507.88 USD

Catalog number X2037E
Supplier nordc
Price 507.88 USD
Size 100 μg
1. Gene info
Identity 15819
Gene ANKRD1
Long gene name ankyrin repeat domain 1
Synonyms gene name
  • ankyrin repeat domain 1 (cardiac muscle)
Synonyms
  • C-193
  • ALRP
  • CARP
  • CVARP
  • MCARP
GenBank acession
  • X83703
Locus 10q23.31
Discovery year 2003-11-10
Entrez gene record 27063
Pubmed identfication
  • 7730328
RefSeq identity
  • NM_014391
Classification
  • Ankyrin repeat domain containing
Havana BLAST/BLAT OTTHUMG00000018734
Locus Specific Databases
  • LRG_379
Category Proteins & Peptides
Long description Human Sirtuin 1 (GenBank Accession No. NM_012238), amino acids 193-741 withN-terminal GST tag, MW=87.2 kDa, expressed in E.coli expression system._x000B__x000B_Sirtuin 1 is a NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Deacetylates Lys-382 of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Involved in HES1- and HEY2-mediated transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal muscle cell differentiation. Despite some ability to deacetylate histones in vitro, such activity is either weak or inexistent in vivo. Inhibited by nicotinamide. Activated by resveratrol (3,5,4'-trihydroxy-trans-stilbene), butein (3,4,2',4'- tetrahydroxychalcone), piceatannol (3,5,3',4'-tetrahydroxy-trans-stilbene),Isoliquiritigenin(4,2',4'-trihydroxychalcone), fisetin (3,7,3',4'-tetrahydroxyflavone) and quercetin (3,5,7,3',4'- pentahydroxyfla.Ivone). 3
Antibody come from Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the N-terminus of the human MMP9 protein and mouse myeloma Ag8563 cells. Sequence common in rabbit, dog and pig
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Clone not specified
Antigen-antibody binding interaction Sirtuin 1 (193-741) - Active Enzyme
Antibody is raised in E.coli
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Enyzme activity assay standard
Antibody's suited for Antibody can be used for Western blotting (1-2 µg/ml) and immunohistochemistry (1-5 µg/ml). Antibody is specific for the activated form of MMP9 only. Optimal concentration should be evaluated by serial dilutions.
Storage -80ºC
Relevant references 1. Wang, L. et al. (2006). Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J. Neurosci. 26(22);5996-6003_x000B__x000B_2. Solmiari, S.B., et al. (2006). Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories. Int. J. Cancer. 119(6);1403-1411_x000B__x000B_3. Chen, X., et al. (2005). Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int. J. Cancer. 116(1);52-61
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Description Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
Gene targetSirtuin 193-741 Active
Short name Sirtuin 1 (193-741) - Active Enzyme
Technique Enzyme
Isotype not specified
Label unlabeled
Alternative name Sirtuin 1 (193-741) - functionnal Enzyme
Alternative technique enzymes
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  • Sirtuin
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