A synthetic peptide that irreversibly inhibits activity of DEVD-dependent caspases (e.g., caspase-3 and caspase-7) and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Z-DEVD-FMK, Z-DEVD-fluoromethylketone, Caspase-3 inhibitor (fluoromethylketone)
Is this a salt?
Is it cell-permeable?
Single spot by TLC
DMSO (20 mM)
Maximum time for storage
Protect from light and moisture
For cells, cell lines and tissues in culture till half confluency.
Z-DEVD-FMK for activation
Z-DEVD-FMK to measure cellular activation