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PRL-2 (2-167) - Active Enzyme

PRL-2 (2-167) - Active Enzyme is available 1 time from Nordc labs

X1658E | PRL-2 (2-167) - Active Enzyme size: 10 μg | 517.29 USD

Catalog number X1658E
Supplier nordc
Price 517.29 USD
Size 10 μg
1. Gene info
Identity 9445
Gene PRL
Long gene name prolactin
GenBank acession
  • D00411
Locus 6p22.3
Discovery year 1986-01-01
Entrez gene record 5617
RefSeq identity
  • NM_000948
Classification
  • Neuropeptides
  • Growth hormone family
Havana BLAST/BLAT OTTHUMG00000016111
2. Gene info
Identity 18923
Gene KRTAP13-2
Long gene name keratin associated protein 13-2
Synonyms
  • KAP13-2
GenBank acession
  • AP001708
Locus 21q22.11
Discovery year 2003-02-21
Entrez gene record 337959
Pubmed identfication
  • 12359730
Classification
  • Keratin associated proteins
Havana BLAST/BLAT OTTHUMG00000057793
3. Gene info
Identity 9635
Gene PTP4A2
Long gene name protein tyrosine phosphatase 4A2
Synonyms gene
  • PTP4A
Synonyms gene name
  • protein tyrosine phosphatase type IVA, member 2
Synonyms
  • HU-PP-1
  • PTPCAAX2
  • OV-1
  • ptp-IV1a
  • PRL-2
  • PRL2
Synonyms name
  • phosphatase of regenerating liver 2
GenBank acession
  • L48723
Locus 1p35.2
Discovery year 1996-03-14
Entrez gene record 8073
Pubmed identfication
  • 8661118
  • 9514946
RefSeq identity
  • NM_080391
Classification
  • Protein tyrosine phosphatase 4A family
Havana BLAST/BLAT OTTHUMG00000003801
Category Proteins & Peptides
Long description Mouse PRL-2, also known as Protein tyrosine phosphatase 4a2 (Ptp4a2) is a unique nuclear protein tyrosine phosphatase (PTP) that plays a central role in regulating diverse cellular processes. PRL-1 is induced in mitogen-stimulated cells and regenerating liver. Mouse PRL-2 exhibit 87% identity to mouse PRL-1 in their amino acid sequences. All mouse PRL proteins contain a C-terminal consensus sequence for prenylation. All PRL proteins bear significant sequence homology to Cdc14p and the tumor suppressor PTEN/MMAC1. PRL-2 is preferentially expressed in skeletal muscle. PRL-2 is also expressed at lower levels in other tissues
Antibody come from Synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho Ser218/222 of human MEK1/2
Other description Provided in HEPES (pH 7.5) solution containing 150 mM NaCl, 100 µg per ml BSA and 50% glycerol
Clone not specified
Antigen-antibody binding interaction PRL-2 (2-167) - Active Enzyme
Antibody is raised in E.coli
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Antibody's suited for Antibody should be used at a 1:1000 dilution to provide for 10 miniblots in Western blotting and dot blots. Antibody detects only phosphorylated protein and does not detect non-phosphorylated protein as shown by the lack of ability of a non-phospho peptide to block the antibody activity. Optimal concentration may be evaluated by serial dilutions.
Storage -20ºC
Relevant references 1. Adams, J.P. and Sweatt, J.D. 'Molecular psychology: Roles for the ERK MAP kinase cascade in memory,' Annu. Rev. Pharmacol. Toxicol. 42, 135-163 (2002). _x000B__x000B_2. Ahn, N.G., et al. 'Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin,' J. Neurochem. 59, 147-156 (1992). _x000B__x000B_3. Ahn, N.G. 'The MAP kinase cascade. Discovery of a new signal transduction pathway,' Mol. Cell Biochem. 127-128, 201-209 (1993). _x000B__x000B_4. Crews, C.M., et al. 'The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product,' Science 258, 478-480 (1992). _x000B__x000B_5. Park, S.H., et al. 'Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms,' Science 299, 1061-1064 (2003)._x000B__x000B_6. Chong H, Vikis HG, Guan KL (2003) Mechanisms of regulating the Raf kinase family. Cellular Signalling 15:463- 469._x000B__x000B_7. Kyriakis JM, Brautigan DL, Ingebritsen TS, Avruch J (1991) pp54 Microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. J Biol Chem 266:10043-10046._x000B__x000B_8. Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG (1991) Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophos- phorylation on both tyrosine and threonine residues: Implications for their mechanism of activation. Proc Natl Acad Sci USA 88:6142-6146.
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Description Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
Gene targetPRL-2 2-167 Active
Short name PRL-2 (2-167) - Active Enzyme
Technique Enzyme
Isotype not specified
Label unlabeled
Alternative name PRL-2 (2-167) - functionnal Enzyme
Alternative technique enzymes
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • PRL-2
  • 2-167
  • Active
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