Lysophosphatidic Acid Receptor 2 (EDG-4) - Membrane Preparation
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Catalog numberX1546MP
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PricePlease ask
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Size50 Tests
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CategoryOther Reagents
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Long descriptionEDG-4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.
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Antibody come fromRecombinant protein consisting of amino acids 321-640 of the human SPT16 protein conjugated to KLH.
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide.
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Clonenot specified
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Antigen antibody binding interactionLysophosphatidic Acid Receptor 2 (EDG-4) - Membrane Preparation
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Antibody is raised insee techfile
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Antibody s reacts withN/A
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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Application[35S]GTPgS Labeling
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Antibody s suited forAntibody can be used for Western blotting (5-10 µg/ml) and immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.
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Storage-80ºC
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Relevant references1. Keller, D.M., et al. 'A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSPT16 and SSRP1.' Mol. Cell Biol. 2001, 7, 283-292
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionAssociated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. , The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbolLPAR2, S1PR5, S1PR1, MIR1302-4, PIRC18, PIRC16, SNORD114-4, IGKV2OR2-4
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Short nameLysophosphatidic Acid Receptor 2 (EDG-4) - Preparation
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Isotypenot specified
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Labelunlabeled
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Alternative nameLysophosphatidic Acid Receptor 2 (EDG-4) - Membrane Preparation
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Gene info
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Identity
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Gene
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Long gene namelysophosphatidic acid receptor 2
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Synonyms gene
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Synonyms gene name
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Lysophosphatidic acid receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesphingosine-1-phosphate receptor 5
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Synonyms gene
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Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-01-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Sphingosine 1-phosphate receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesphingosine-1-phosphate receptor 1
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Synonyms gene
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Synonyms gene name
- endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-05-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Sphingosine 1-phosphate receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-4
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 18
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 16
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 114-4
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Synonyms
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Locus
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Discovery year2006-09-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 2/OR2-4 (pseudogene)
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Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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Pubmed identfication
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Classification
- Immunoglobulin kappa (IGK) orphons
