Lysophosphatidic Acid Receptor 3 (EDG-7) - Membrane Preparation

• Catalog number
  X1275MP
• Price
  Please ask
• Size
  50 Tests

• Category
  Other Reagents
• Long description
  Endothelial Cell Differentiation Gene-7 (EDG-7) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-7 is lysophospholipid. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-7 is expressed in prostate as well as other tissues.
• Antibody come from
  Hybridoma produced by the fusion of spelocytes from BALB/c mice immunized with recombinant protein corresponding to amino acids 1-206 of murine p59fyn and mouse myeloma p3-NS1-Ag4-1 cells.
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide.
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Lysophosphatidic Acid Receptor 3 (EDG-7) - Membrane Preparation
• Antibody is raised in
  see techfile
• Antibody s reacts with
  N/A
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  [35S]GTPgS Labeling
• Antibody s suited for
  This antibody can be used for Western blotting (1-5 µg/ml), immunohistochemistry on acetone-fixed frozen sections, immunoprecipitation (2 µg/mg of protein lysate) and ELISA. Optimal concentration should be evaluated by serial dilutions.
• Storage
  -80ºC
• Relevant references
  1. Ley SC; et al. Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes. J. Cell. Biol., 1994 May, 125(3):639-49._x000B__x000B_2. Bhat NR. Signal transduction mechanisms in glial cells. Dev. Neurosci, 1995, 17(5-6):267-84._x000B__x000B_3. Fusaki N; et al. Int Immunol, 1994, 6:1245-55. _x000B__x000B_4. Guy CT; et al. Genes Dev, 1994, 8:23-32.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. , The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Lysophosphatidic   Acid   Receptor   EDG-7   Membrane   Preparation  
• Gene symbol
  LPAR3, PIRC34, PIRC33, S1PR5, PIRC32, SNORD114-7, IGHV3OR15-7, SNORD115-7, RNU6-7, S1PR1
• Short name
  Lysophosphatidic Acid Receptor 3 (EDG-7) - Preparation
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  Lysophosphatidic Acid Receptor 3 (EDG-7) - Membrane Preparation

Gene info

• Identity
  HGNC:14298
• Gene
  LPAR3
• Long gene name
  lysophosphatidic acid receptor 3
• Synonyms gene
  • EDG7
• Synonyms gene name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
• Synonyms
  • LP-A3
  • Edg-7
  • RP4-678I3
  • HOFNH30
  • LPA3
• GenBank acession
  • AF127138
• Locus
  1p22.3
• Discovery year
  2001-01-02
• Entrez gene record
  23566
• Pubmed identfication
  • 10488122
• RefSeq identity
  • NM_012152
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000009925

Gene info

• Identity
  HGNC:37538
• Gene
  PIRC34
• Long gene name
  piwi-interacting RNA cluster 34
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313890
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37537
• Gene
  PIRC33
• Long gene name
  piwi-interacting RNA cluster 33
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313854
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:14299
• Gene
  S1PR5
• Long gene name
  sphingosine-1-phosphate receptor 5
• Synonyms gene
  • EDG8
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
• Synonyms
  • Edg-8
• GenBank acession
  • AK074661
• Locus
  19p13.2
• Discovery year
  2001-01-02
• Entrez gene record
  53637
• Pubmed identfication
  • 10799507
• RefSeq identity
  • NM_030760
• Classification
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000180581

Gene info

• Identity
  HGNC:37536
• Gene
  PIRC32
• Long gene name
  piwi-interacting RNA cluster 32
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313811
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:32995
• Gene
  SNORD114-7
• Long gene name
  small nucleolar RNA, C/D box 114-7
• Synonyms
  • 14q(II-7)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767583
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003199.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5633
• Gene
  IGHV3OR15-7
• Long gene name
  immunoglobulin heavy variable 3/OR15-7 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3/OR15-7
  • immunoglobulin heavy variable 3/OR15-7 pseudogene
• Synonyms
  • IGHV3/OR15-7
• GenBank acession
  • Z29597
• Locus
  15q11.2
• Discovery year
  2000-04-17
• Entrez gene record
  28318
• Classification
  • Immunoglobulin heavy (IGH) orphons
• VEGA ID
  OTTHUMG00000171835

Gene info

• Identity
  HGNC:33026
• Gene
  SNORD115-7
• Long gene name
  small nucleolar RNA, C/D box 115-7
• Synonyms
  • HBII-52-7
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033444
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003299.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:34284
• Gene
  RNU6-7
• Long gene name
  RNA, U6 small nuclear 7
• Synonyms
  • U6-7
• Locus
  14q12
• Discovery year
  2008-06-10
• Entrez gene record
  101954275
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_104084
• Classification
  • Small nuclear RNAs

Gene info

• Identity
  HGNC:3165
• Gene
  S1PR1
• Long gene name
  sphingosine-1-phosphate receptor 1
• Synonyms gene
  • EDG1
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
• Synonyms
  • edg-1
  • D1S3362
  • CD363
• GenBank acession
  • M31210
• Locus
  1p21.2
• Discovery year
  1998-05-15
• Entrez gene record
  1901
• Pubmed identfication
  • 2160972
  • 9488656
• RefSeq identity
  • NM_001400
• Classification
  • CD molecules
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000010835

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