Ceramide Kinase (CERK) - Active Enzyme

  • Catalog number
    X2076E
  • Price
    Please ask
  • Size
    10 μg
  • Category
    Proteins & Peptides
  • Long description
    Sphingolipids, in addition to being structural components of membranes, regulate cell-cell and cell-substrate interactions, proliferation, and differentiation. Members of this diverse group of lipids have emerged as a novel class of signaling molecules that also regulate phagocytosis. The mechanisms by which sphingolipids exert these effects remain incompletely defined. More than a decade ago, it was found that ceramide can be phosphorylated to ceramide 1-phosphate (C1P). Ceramide kinase (CERK) and its phosphorylated product ceramide 1-phosphate (C1P) are central players in inflammation and cancer. The product of CERK activity, ceramide 1-phosphate (C1P), has been reported to have mitogenic effects. C1P is a direct activator of cytosolic phospholipase A2 and is involved in arachidonic acid release. CERK is a mediator of Ca2+-dependent degranulation in mast cells. In both arachidonic acid release and mast cell degranulation, the intracellular elevation of Ca2+ is a central event that acts as a regulatory mechanism of CERK activity. C1P is found in brain synaptic vesicles, and plays a role in regulating the secretion of neurotransmitters. CERK activity exists in HL-60 cells where the C1P is derived from ceramide released from sphingomyelin. The expressed kinase has specific ceramide phosphorylating activity. CERKs exist in a variety of cellular organisms, including plants, nematodes, insects, and vertebrates.
  • Antibody come from
    Synthetic protein made to the 3rd cytoplasmic domain of human Muscarinic Acetylcholine Receptor M3 linked to KLH
  • Other description
    Phosphate buffered saline containing 0.1% sodium azide.
  • Clone
    not specified
  • Antigen antibody binding interaction
    Ceramide Kinase (CERK) - Active Enzyme
  • Antibody is raised in
    Sf9 cells
  • Antibody s reacts with
    Human
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
  • Antibody s suited for
    Antibody can be used for immunohistochemistry (5-10µg/ml). Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    no information yet
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
  • Gene target
    Ceramide   Kinase   CERK   Active  
  • Gene symbol
    CERK
  • Short name
    Ceramide Kinase (CERK) - Active Enzyme
  • Technique
    Enzyme, enzymes
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    Ceramide phosphorylation catalyst (ceramide kinase) - functionnal Enzyme
  • Alternative technique
    enzymes
  • Alternative to gene target
    ceramide kinase, CERK and IDBG-12219 and ENSG00000100422 and 64781, ATP binding, Plasma membranes, Cerk and IDBG-171293 and ENSMUSG00000035891 and 223753, CERK and IDBG-642451 and ENSBTAG00000046654 and
Gene info
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