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Rabbit anti Caspase

Rabbit anti Caspase is available 12 times from Nordc labs

X1113P | Rabbit anti Caspase-10 (CT) (flICE2) size: 100 μg | 436.64 USD

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X1114P | Rabbit anti Caspase-12 (IN) size: 100 μg | 436.64 USD

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X1115P | Rabbit anti Caspase-12 (NT) (involved in Alzheimers) size: 100 μg | 436.64 USD

Catalog number X1115P
Supplier nordc
Price 436.64 USD
Size 100 μg
Long description Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in AlzheimerÕs disease including -secretase presenilin and -amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid- . Caspase-12 is ubiquitously expressed in mouse tissues (1).
Antibody come from Synthetic peptide corresponding to amino acids 2 to 17 of the murine caspase-12
Other description Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative. Antigen Immunoaffiinity Purification
Antigen-antibody binding interaction Rabbit anti Caspase-12 (NT) (involved in Alzheimers) Antibody
Antibody's reacts with Human, Mouse, Rat
Application Western Blot
Antibody's suited for Detects caspase-12 by Western blot at 0.5 to 1.0 µg/ml. Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Nakagawa, T., et al., Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403, 98-103._x000B__x000B_2. Mehmet, H., Caspases find a new place to hide. Nature 2000, 403, 29-30_x000B__x000B_3. Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett 1997, 403, 61-9
Gene targetCaspase-12 involved Alzheimers
Short name Rabbit anti Caspase-12 (NT) (involved in Alzheimers)
Alternative name production species: rabbit antibody to caspase-12 (NT) (involved in Alzheimers)
Disease alzheimer
1. Gene info
Identity 8024
Gene NTF4
Long gene name neurotrophin 4
Synonyms gene
  • NTF5
Synonyms gene name
  • neurotrophin 5 (neurotrophin 4/5)
Synonyms
  • NT-4/5
  • GLC1O
Synonyms name
  • neurotrophic factor 4
Locus 19q13.33
Discovery year 1992-10-15
Entrez gene record 4909
Pubmed identfication
  • 1496419
RefSeq identity
  • NM_006179
Classification
  • Neurotrophins
Havana BLAST/BLAT OTTHUMG00000191728

X1116P | Rabbit anti Caspase-13 (ERICE) (Evolutionary Rel ICE) size: 100 μg | 436.64 USD

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A130P | Rabbit anti Caspase-3 size: 100 μg | 359.72 USD

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X1785P | Rabbit anti Caspase-4 (NT) size: 100 μg | 436.64 USD

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X1786P | Rabbit anti Caspase-5 (IN) size: 100 μg | 436.64 USD

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X1787P | Rabbit anti Caspase-5 (NT) size: 100 μg | 436.64 USD

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A135P | Rabbit anti Caspase-7 size: 100 μg | 359.72 USD

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A140P | Rabbit anti Caspase-9 size: 100 μg | 359.72 USD

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X1111P | Rabbit anti Caspase-9 (IN1) size: 100 μg | 436.64 USD

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X1112P | Rabbit anti Caspase-9 (IN2) size: 100 μg | 436.64 USD

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Category Primary Antibodies
Clone Polyclonal
Antibody is raised in Rabbit
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Storage -20ºC
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
About Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name Oryctolagus cuniculus
Technique Rabbit, anti
Host Rabbit
Isotype not specified
Label unlabeled
Alternative technique rabbit-anti
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Rabbit anti Caspase-12 (NT) (involved in Alzheimers) | Techn
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • Caspase-10
  • flICE2
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