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Rabbit anti ADAM

Rabbit anti ADAM is available 3 times from Nordc labs

X1106P | Rabbit anti ADAM 10 (CT) (kuz) (TNFa converting enzyme) size: 100 μg | 447.34 USD

Catalog number X1106P
Supplier nordc
Price 447.34 USD
Size 100 μg
Long description Proinflammatory cytokine tumor necrosis factor- (TNF- ) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF- , notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF- , notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).
Antibody come from Synthetic peptide corresponding to amino acids 732 to 748 off the human ADAM10. Immungen sequence is identical in bovine and rat and differs from the mouse protein by one amino acid.
Other description Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative. Antigen Immunoaffiinity Purification
Antigen-antibody binding interaction Rabbit anti ADAM 10 (CT) (kuz) (TNFa converting enzyme) Antibody
Antibody's reacts with Human, Mouse, Rat
Application Western Blot
Antibody's suited for Detects ADAM10 by Western blot at 0.25 to 1 µg/ml. Detects an 85 kDa band can be detected in Jurkat cell lysates which may represent precursor protein. A faint 60 kDa band is also detected in some cell lines, including Jurkat, which may be processed mature protein. Optimal concentration should be evaluated by serial dilutions.
Storage -20ºC
Relevant references 1. Rosendahl, M.S., et al., Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. J. Biol. Chem. 1997, 272, 24588-24593_x000B__x000B_2. Pan, D. & Rubin, G.M., Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 1997, 90, 271-280_x000B__x000B_3. Qi, H., et al., Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science 1999, 283, 91-94 _x000B__x000B_4. Howard, L., et al., Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Biochem. J. 1996, 317, 45-50
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
About Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name Oryctolagus cuniculus
Gene targetADAM kuz TNFa converting
Short name Rabbit anti ADAM 10 (CT) (kuz) (TNFa converting enzyme)
Technique Enzyme, Rabbit, anti
Alternative name production species: rabbit antibody to ADAM 10 (CT) (kuz) (TNFa converting enzyme)
Alternative technique enzymes
1. Gene info
Identity 13201
Gene ADAMTS10
Long gene name ADAM metallopeptidase with thrombospondin type 1 motif 10
Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
Synonyms
  • ADAM-TS10
GenBank acession
  • AF163762
Locus 19p13.2
Discovery year 2001-04-05
Entrez gene record 81794
Pubmed identfication
  • 15355968
  • 15368195
RefSeq identity
  • NM_030957
Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
Havana BLAST/BLAT OTTHUMG00000182216
2. Gene info
Identity 2499
Gene CTF1
Long gene name cardiotrophin 1
Synonyms
  • CT-1
  • CT1
GenBank acession
  • U43030
Locus 16p11.2
Discovery year 1995-05-01
Entrez gene record 1489
Pubmed identfication
  • 8833032
RefSeq identity
  • NM_001330
Classification
  • Interleukin 6 type cytokine family
Havana BLAST/BLAT OTTHUMG00000132413
Locus Specific Databases
  • LRG_408

X2727P | Rabbit anti ADAM DEC1 size: 10MinibLots | 509.17 USD

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X2416P | Rabbit anti ADAM DEC1 size: 100 μg | 368.54 USD

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Category Primary Antibodies
Clone Polyclonal
Antibody is raised in Rabbit
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Host Rabbit
Isotype not specified
Label unlabeled
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Rabbit anti ADAM 10 (CT) (kuz) (TNFa converting enzyme) | Te
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  • ADAM
  • kuz
  • TNFa
  • converting
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