HLCL-61 hydrochloride

  • Catalog number
    B1209-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
  • Description
    HLCL-61 is a potent and selective PRMT5 (potent arginine methyltransferase 5) inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members.  In vitro data shows HLCL-61 effectively inhibits symmetric arginine demethylation of histones H3 and H4 in AML samples. HLCL-61 treatment of cells showed decrease in cell vitality and effective in apoptosis promotion in MV-11 and THP-1 cells after 48 hours.
  • CAS Number
    586395-74-6 (free base).
  • Structure Available
    Yes
  • Salt Form
    Yes
  • Molecular Formula
    C₂₃H₂₅ClN₂O
  • Molecular Weight
    380.92
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO(>20 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A selective PRMT5(potent arginine methyltransferase 5) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    17208222
  • SMILES
    CN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl
  • InChi
    InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
  • InChi Key
    XYAVCNMZZKTEGR-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    IGHV4-61, SNORA81, IGLV8-61, RNU6-61P, SCARNA2, SH3GLB1
  • Short name
    HLCL-61 hydrochloride
  • Alternative name
    HLCL-61 hydrochloride
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    RNA, U6 small nuclear 61, pseudogene
  • Synonyms gene
  • Synonyms gene name
    • RNA, U6 small nuclear 61
  • Locus
  • Discovery year
    2011-08-08
  • Entrez gene record
Gene info
Gene info
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