mlN4924, NEDD8 activating enzyme inhibitor

  • Catalog number
    SIH-331-1MG
  • Price
    Please ask
  • Size
    1 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    905579-51-3
  • Description
    NEDD8 activating enzyme inhibitor
  • Molecular weight
    443,2 g/mol
  • Primary research fields
    Cancer, Apoptosis
  • Other name
    [(1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, Sulfamic acid
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C21H25N5O4S
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble in 10 mg/ml DMSO
  • Physical appearance
    White Powder
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
  • PubChem number
    16720766
  • Scientific context
    Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.
  • Bibliography
    1. Soucy T.A., et al. (2009) Nature. 458:732. 2. Milhollen M.A., et al. (2010) Blood. 116:1515.
  • Release date
    6-Jun-2012
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of MLN4924 (SIH-331), a Nedd8 activating enzyme inhibitor. CAS #: 905579-51-3. Molecular Formula: C21H25N5O4S. Molecular Weight: 443.2 g/mol. Chemical structure of MLN4924, a Nedd8 activating enzyme inhibitor (SIH-331). CAS # 905579-51-3. Molecular Formula: C21H25N5O4S.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.001
  • Additional description
    Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    NEDD8-MDP1, NEDD8
  • Short name
    mlN4924, NEDD8 activating enzyme inhibitor
  • Technique
    Enzyme, enzymes
  • Alternative name
    mlN4924, NEDD8 activating enzyme suppressor
  • Alternative technique
    enzymes
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    NEDD8 ubiquitin like modifier
  • Synonyms gene name
    • neural precursor cell expressed, developmentally down-regulated 8
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1994-01-21
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • VEGA ID
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