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mlN4924 NEDD8 activating enzyme inhibitor

mlN4924 NEDD8 activating enzyme inhibitor is available 2 times from Stressma labs

SIH-331-1MG | mlN4924, NEDD8 activating enzyme inhibitor size: 1 mg | 1,160.18 USD

Catalog number SIH-331-1MG
Supplier stressma
Price 1,160.18 USD
Size 1 mg
Net weight (g) 0.001
1. Gene info
Identity 7732
Gene NEDD8
Long gene name neural precursor cell expressed, developmentally down-regulated 8
Synonyms
  • Nedd-8
GenBank acession
  • D23662
Locus 14q12
Discovery year 1994-01-21
Entrez gene record 4738
Pubmed identfication
  • 9353319
RefSeq identity
  • NM_006156
Havana BLAST/BLAT OTTHUMG00000029325

SIH-331-200UG | mlN4924, NEDD8 activating enzyme inhibitor size: 200 µg | 347.03 USD

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Origin Synthetic
Soluble in Soluble in 10 mg/ml DMSO
Other name [(1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, Sulfamic acid
PubMed number Refer to PubMed
Description NEDD8 activating enzyme inhibitor
Warning information Non-hazardous
Representative figure legend Chemical structure of MLN4924 (SIH-331), a Nedd8 activating enzyme inhibitor. CAS #: 905579-51-3. Molecular Formula: C21H25N5O4S. Molecular Weight: 443.2 g/mol. Chemical structure of MLN4924, a Nedd8 activating enzyme inhibitor (SIH-331). CAS # 905579-51-3. Molecular Formula: C21H25N5O4S.
Stock availabilitIn Stock In Stock
Molecular weight 443,2 g/mol
Purity pourcentage >98%
Chemical formula C21H25N5O4S
Tested applications To be tested
Primary research fields Cancer, Apoptosis
Total weight (kg) 0.25
Release date 6-Jun-2012
Scientific context Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.
Product type Inhibitor
CAS number 905579-51-3
Safety information Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Country of production Canada
Product category Small Molecules
Physical appearance White Powder
Tested reactivity To be tested
PubChem number 16720766
Bibliography 1. Soucy T.A., et al. (2009) Nature. 458:732. 2. Milhollen M.A., et al. (2010) Blood. 116:1515.
Storage recommendations -20ºC
Shipping recommendations Shipped Ambient
Additional description Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Gene targetmlN4924 NEDD8 activating inhibitor
Short name mlN4924, NEDD8 activating enzyme inhibitor
Technique Enzyme
Alternative name mlN4924, NEDD8 activating enzyme suppressor
Alternative technique enzymes
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