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Rabbit Anti-Human VEGF Receptor 1 (pTyr1048) Polyclonal: ATTO 680

  • Catalog number
    SPC-1095D-A680
  • Product name
    Rabbit Anti-Human VEGF Receptor 1 (pTyr1048) Polyclonal: ATTO 680
  • Size
    100 µl
  • Label
    ATTO 680
  • Immunogen
    A phospho-specific peptide corresponding to residues surrounding Tyr1048 of human VEGF Receptor 1 (AA1045-1051)
  • Antibody s target
    Human VEGF Receptor 1 (pTyr1048)
  • Antibody s full description
    Rabbit Anti-Human VEGF Receptor 1 (pTyr1048) Polyclonal
  • Antibody s category
    Polyclonal Antibodies
  • Antibody s other name
    EC 2.7.10.1 Antibody, FLT 1 Antibody, FLT Antibody, Flt-1 Antibody, FLT1 Antibody, Fms like tyrosine kinase 1 Antibody, Fms related tyrosine kinase 1 Antibody, Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Antibody, Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor Antibody, Fms-like tyrosine kinase 1 Antibody, FRT Antibody, Soluble VEGF receptor 1 14 Antibody, Soluble VEGFR1 variant 2 Antibody, Soluble VEGFR1 variant 21 Antibody, Tyrosine protein kinase FRT Antibody, Tyrosine protein kinase receptor FLT Antibody, Tyrosine-protein kinase FRT Antibody, Tyrosine-protein kinase receptor FLT Antibody, Vascular endothelial growth factor receptor 1 Antibody, Vascular endothelial growth factor vascular permeability factor receptor Antibody, Vascular permeability factor receptor 1 Antibody, Vascular permeability factor receptor Antibody, VEGFR 1 Antibody, VEGFR-1 Antibody, VEGFR1 Antibody, VGFR1_HUMAN Antibody
  • Verified applications
    WB, AM
  • Raised in
    Rabbit
  • Isotype
    Immunoglobulin
  • Antibody s reactivity
    Human
  • Antibody s recommended dilutions for use
    WB (1:250); optimal dilutions for assays should be determined by the user.
  • Antibody s purified from
    Peptide Affinity Purified
  • Recommended buffer for storage
    PBS pH7.4, 50% glycerol, 0.025% Thimerosal
  • Antibody s concentration
    See included datasheet or contact our support service
  • Antibody s specificity
    Detects 151 kDa.
  • Storage recommendations
    -20°C
  • Shipping recommendations
    Blue Ice or 4°C
  • Certificate of analysis
    A 1:250 dilution of SPC-1095 was sufficient for detection of VEGF Receptor 1 (pTyr1048) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
  • Antibody in cell
    Cell membrane, Secreted, Cytoplasm
  • Tissue specificity
    Detected in lung, placenta, liver, kidney, heart and brain tissues. Expressed in most vascular endothelial cells.
  • Scientific context
    FLT1 is a receptor-tyrosine kinase that is activated upon binding with VEGF-A, VEGF-B and PGF. It plays an important role in the development of embryonic vasculature, and as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. However, it can promote PGF-mediated endothelial cell proliferation, survival and angiogenesis in adults, although this seems to be cell-type specific. It also contributes to cancer cell survival, proliferation, migration, and invasion, as well as tumour angiogenesis, metastasis, and recruitment of tumour-infiltrating macrophages. It has a very high affinity for VEGF-A and may function as a negative regulator of VEGF-A signalling by limiting the amount of free VEGF-A and preventing its binding to KDR. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGF-A. Furthermore, it mediates phosphorylation of PI3K, leading to activation of the downstream signalling pathway, as well as mediating the activation of the MAPK signalling pathway, and of the Akt/PKB signalling pathway.
  • Bibliography
    Refer to PubMed
  • Released date
    29/Aug/2016
  • NCBI number
    NP_002010
  • Gene number
    2321
  • Protein number
    P17948
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Antibody s datasheet
    Contact our support service to receive datasheet or other technical documentation.
  • Representative figure link
    No Data Available
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    1.4
  • Net weight g
    0.1
  • Stock availabilit
    In Stock
  • Other related products
    Other_related_products
  • Gene target
    VEGF Receptor 1 pTyr1048 ATTO 680
    • Gene info
    Locus Specific Databases:ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
    Gene info
    Gene info
    Locus Specific Databases:Global Variome shared LOVD
  • Gene symbol
    VEGFA, VEGFC, VEGFD
  • Host
    Rabbit, Rabbits
  • isotype filter
    • Immunoglobulin
  • Short name
    Rabbit Anti- VEGF Receptor 1 (pTyr1048) Polyclonal: ATTO 680
  • label filter
    • ATTO 680
  • technique filter
    • anti-Human
    • Polyclonal
    • Rabbit
    • anti-
    • anti
  • Technique
    anti-Human, Polyclonal, Rabbit, anti-, anti, antibody to, antibodies, antibodies against human proteins, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
  • Alternative technique
    polyclonals, rabbit-anti, antibodies