- Catalog number1P-736-T100
- Product nameCD88 / C5aR monoclonal antibody
- Size100 assays
- PriceAsk For Price
- Short nameAnti-CD88 / C5aR Mab
- Long nameMouse Monoclonal Antibody against Human CD88 / C5aR, Clone: S5/1
- AntigenCD88 / C5aR
- HostMouse (Mus musculus)
- Species reactivityHuman (Homo sapiens), Bovine, Ferret, Rabbit
- Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
- ClonalityMonoclonal Antibody (Mab)
- CloneS5/1
- IsotypeIgG2a
- ApplicationsFC, IP, WB, IHC(P)
- ImmunogenRecombinant N-terminal peptide (Asp15-Asp27) of human C5aR
- Format conjugationPE
- SpecificityThe mouse monoclonal antibody S5/1 recognizes the CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
- Research areaCD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
- Storage bufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
- Shipping and storageMouse Monoclonal Antibody against Human CD88 / C5aR, Clone: S5/1 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
- BackgroundCD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.
- Purity> 95% (by SDS-PAGE)
- Purification methodPurified by affinity chromatography
- Datasheet
- References*Camous L, Roumenina L, Bigot S, Brachemi S, Frémeaux-Bacchi V, Lesavre P, Halbwachs-Mecarelli L: Complement alternative pathway acts as a positive feedback amplification of neutrophil activation. Blood. 2011 Jan 27;117(4):1340-9., *Cain SA, Monk PN: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J Biol Chem. 2002 Mar 1;277(9):7165-9., *Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C, Rossi AG, Sallenave JM, Simpson AJ: C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med. 2009 Jul 1;180(1):19-28., *Kiener HP, Baghestanian M, Dominkus M, Walchshofer S, Ghannadan M, Willheim M, Sillaber C, Graninger WB, Smolen JS, Valent P: Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis. Arthritis Rheum. 1998 Feb;41(2):233-45.
- Gene targetCD88 / C5aR monoclonal
- Identity:HGNC:1338
- Gene:C5AR1
- Long gene name:complement C5a receptor 1
- Synonyms gene name:complement component 5 receptor 1 (C5a ligand), complement component 5a receptor 1
- Synonyms:C5A, C5ARCD88
- Discovery year:1991-12-04
- Entrez gene record:728
- Pubmed identification:1612600
- RefSeq identity:NM_001736
- Classification:Complement component GPCRs, Complement system regulators and receptors, CD molecules
- VEGA ID:OTTHUMG00000183504
- Gene symbolC5AR1
- isotype filter
- IgG2a
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
- Alternative techniqueantibodies