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Mouse Anti-Mouse LRP4 (Extracellular) Monoclonal IgG2A, Clone S207-27

  • Catalog number
    SMC-418S
  • Product name
    Mouse Anti-Mouse LRP4 (Extracellular) Monoclonal IgG2A, Clone S207-27
  • Size
    12 µg
  • Label
    Unconjugated
  • Clone
    S207-27
  • Immunogen
    Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4
  • Antibody s full description
    Mouse Anti-Mouse LRP4 Monoclonal IgG2A Antibody, Clone: S207-27: Unconjugated
  • Antibody s category
    Monoclonal Antibodies
  • Antibody s other name
    Corin Antibody, KIAA0816 Antibody, LDLR Antibody, LDLR dan Antibody, Low density lipoprotein receptor related protein 4 Antibody, LRP-4 Antibody, LRP10 Antibody, MEGF7 Antibody, Multiple epidermal growth factor like domains 7 Antibody
  • Raised in
    Mouse
  • Isotype
    IgG2A, IgG2a
  • Antibody s target
    LRP4
  • Primary research fields
    Neuroscience, Cell Structure, Membrane Markers, Cell Signaling
  • Brandname
    None
  • Antibodies applications
    WB, ICC/IF
  • Antibody s reactivity
    Human, Mouse, Rat
  • Antibody s dilutions
    WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
  • Purity
    Protein G Purified
  • Antibody buffer for storage
    PBS pH7.4, 50% glycerol, 0.09% sodium azide
  • Antibody s concentration
    1 mg/ml
  • Antibody s specificity
    Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Blue Ice or 4ºC
  • Antibody certificate of analysis
    1 µg/ml of SMC-418 was sufficient for detection of LRP4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
  • Antibody in cell
    Membrane
  • Tissue specificity
    See included datasheet or contact our support service
  • Scientific context
    Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. It is involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
  • Bibliography
    1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.
  • Released date
    27-Feb-2013
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • NCBI number
    NP_766256.3
  • Gene number
    83469
  • Protein number
    Q8VI56
  • Antibody s datasheet
    Contact our support service
  • Representative figure link
    Representative_figure_link
  • Representative figure legend
    Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-LRP4 (Extracellular) Monoclonal Antibody, Clone S207-27 (SMC-418). Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-LRP4 (Extracellular) Monoclonal Antibody (SMC-418) at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) LRP4 (Extracellular) Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of LRP4 protein using Mouse Anti-LRP4 Monoclonal Antibody, Clone S207-27 (SMC-418). Primary Antibody: Mouse Anti-LRP4 Monoclonal Antibody (SMC-418) at 1:500, 1:1000, and 1:2000. Mouse Anti-LRP4 (Extracellular) Antibody [S207-27] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Neuroblastoma cell line SK-N-BE (SMC-418) Mouse Anti-LRP4 Antibody [S207-27] used in Western Blot (WB) on Rat brain membrane lysate (SMC-418)
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    1.4
  • Net weight g
    0.012
  • Stock availability
    In Stock
  • Other related products
    Other_related_products
  • Alternative to gene target
    • [ "low density lipoprotein receptor-related protein 4", "CLSS and LRP-4 and LRP10 and MEGF7 and SOST2", "LRP4 and IDBG-42508 and ENSG00000134569 and 4038", "scaffold protein binding", "Cell surfaces", "Lrp4 and IDBG-191212 and ENSMUSG00000027253 and 228357", "BT.103632 and IDBG-637271 and ENSBTAG00000008429 and 504317" ]
  • Gene target
    LRP4 Extracellular Monoclonal IgG2A S207-27
    • Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    • Identity:HGNC:54431
    • Gene:RNVU1-27
    • Long gene name:RNA, variant U1 small nuclear 27
    • Discovery year:2019-07-26
    • Classification:Variant U1 small nuclear RNAs
    Gene info
    Gene info
    Gene info
    Gene info
  • Gene symbol
    LRP4-AS1, SNORD115-27, IGKV1D-27, ERVK-27, ERVW-27, RNVU1-27, IGHV7-27, SNORD116-27, SNORD114-27, IGLV3-27
  • Host
    mouse
  • isotype filter
    • IgG2A
  • Short name
    Mouse Anti-Mouse LRP4 (Extracellular) Monoclonal IgG2A, Clone S207-27
  • label filter
    • Unconjugated
  • Clone name
    S207-27
  • technique filter
    • anti-
    • Mouse
    • anti
  • Technique
    anti-, Mouse, anti, antibody to, antibodies, Monoclonals or monoclonal antibodies, mouses
  • Alternative technique
    murine, antibodies