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P32/98, DPPIV/DPP4 inhibitor

  • Catalog number
    SIH-385-10MG
  • Product name
    P32/98, DPPIV/DPP4 inhibitor
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    136259-20-6
  • Description
    DPPIV/DPP4 inhibitor
  • Molecular weight
    260,4 g/mol
  • Primary research fields
    Cell Signaling
  • Other name
    3-N-[((2S,3S)-2-Amino-3-methylpentanoyl]-1,3-thiazolidine. hemi-fumarate, (2S,3S)-2-Amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one fumarate
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C9H18N2OS•0.5C4H4O4
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble in water (20 mg/ml) or DMSO (25 mg/ml)
  • Physical appearance
    White solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes
  • PubChem number
    77519185
  • Scientific context
    P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8).
  • Bibliography
    1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11. 2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8. 3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94. 4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50. 5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83. 6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50. 7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11. 8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.
  • Release date
    17-Jul-2013
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure link
    Representative_figure_link
  • Representative figure legend
    Chemical structure of P32/98 (SIH-385), a DPPIV/DPP4 inhibitor. CAS #: 136259-20-6. Molecular Formula: C9H18N2OS . 0.5 C4H4O4. Molecular Weight: 260.4 g/mol. Chemical structure of P32/98, a DPPIV/DPP4 inhibitor (SIH-385). CAS # 136259-20-6. Molecular Formula: C9H18N2OS . 0.5 C4H4O4.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Other related products
    Other_related_products
  • Alternative to gene target
    • [ "dipeptidyl-peptidase 4", "ADABP and ADCP2 and CD26 and DPPIV and TP103", "DPP4 and IDBG-73658 and ENSG00000197635 and 1803", "protein homodimerization activity", "Cell surfaces", "Dpp4 and IDBG-173968 and ENSMUSG00000035000 and 13482", "DPP4 and IDBG-641297 and ENSBTAG00000015330 and" ]
  • Gene target
    P32/98 DPPIV/DPP4 inhibitor
    • Gene info
    Gene info
    • Identity:HGNC:40191
    • Gene:DPP4-DT
    • Long gene name:DPP4 divergent transcript
    • Discovery year:2019-07-25
    • Entrez gene record:100131604
    • RefSeq identity:NR_147697
    • Classification:Divergent transcripts
    Gene info
    Gene info
  • Gene symbol
    DPP4, DPP4-DT, FAP, C1QBP
  • Short name
    P32/98, DPPIV/DPP4 inhibitor