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KT5720, PKA kinase inhibitor

  • Catalog number
    SIH-457-100UG
  • Product name
    KT5720, PKA kinase inhibitor
  • Size
    100 µg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    108068-98-0
  • Description
    PKA kinase inhibitor
  • Molecular weight
    537,6 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C32H31N3O5
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (TLC)
  • Soluble in
    Soluble in methanol: clear colorless solution at 5 mg/ml
  • Physical appearance
    White powder
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Specific target organ toxicity-single exposure (Category 1), H370 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H370 Causes damage to organs. Precautionary statements: P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant
  • PubChem number
    3844
  • Scientific context
    KT5720 is a potent and selective inhibitor of protein kinase A (PKA). This compound blocks PKA signaling through competitive inhibition. It causes no significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (mlCK). KT5720 has been shown to reversibly arrests human skin fibroblasts in the G1 phase. It is cell permeable.
  • Bibliography
    1. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440. 2. Gadbois D.M., Crissman H.A., Tobey R.A., & Bradbury E.M. (1992) Pro. Na. Aca. Sci. USA. 89(18): 8626–8630.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure link
    Representative_figure_link
  • Representative figure legend
    Chemical structure of KT5720 (SIH-457), a PKA kinase inhibitor. CAS #: 108068-98-0. Molecular Formula: C32H31N3O5. Molecular Weight: 537.6 g/mol. Chemical structure of KT5720, a PKA kinase inhibitor (SIH-457). CAS # 108068-98-0. Molecular Formula: C32H31N3O5.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.0001
  • Other related products
    Other_related_products
  • Gene target
    KT5720 PKA kinase inhibitor
  • Short name
    KT5720, PKA kinase inhibitor