- Catalog numberbs-13018R-HRP
- Product nameDNA Polymerase iota Antibody, HRP Conjugated
- Size0.1ml
- PriceAsk For Price
- Short nameAnti-DNA Polymerase iota
- Long nameDNA Polymerase iota Polyclonal Antibody, HRP Conjugated
- CategoryConjugated Primary Antibodies
- ConjugationHRP
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenDNA Polymerase iota
- SpecificityThis is a highly specific antibody against DNA Polymerase iota.
- ModificationUnmodified
- Modification siteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- SourceKLH conjugated synthetic peptide derived from human DNA Polymerase iota
- Gene ID number11201
- Tested applicationsWB, IHC-P
- Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500)
- CrossreactivityHuman, Mouse, Rat
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundDNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
- Purification methodThis antibody was purified via Protein A.
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation EmissionN/A
- SynonymsDNA polymerase iota; Eta 2; Eta2; POLI; POLI_HUMAN; Polymerase DNA directed iota; RAD 30B; RAD30 homolog B; RAD30B; RAD3OB.
- Gene targetDNA Polymerase iota Conjugated
- Identity:HGNC:9413
- Gene:PRKDC
- Long gene name:protein kinase, DNA-activated, catalytic subunit
- Synonyms gene name:protein kinase, DNA-activated, catalytic polypeptide
- Synonyms:DNPK1p350DNAPKXRCC7DNA-PKcsDNAPKcDNA-PKCp460
- Discovery year:1993-11-09
- Entrez gene record:5591
- Pubmed identification:7638222
- RefSeq identity:NM_001081640
- Classification:Armadillo like helical domain containing
- VEGA ID:OTTHUMG00000164239
- Identity:HGNC:4936
- Gene:HLA-DOA
- Long gene name:major histocompatibility complex, class II, DO alpha
- Synonyms:HLA-D0-alpha
- Discovery year:2001-06-22
- Entrez gene record:3111
- Pubmed identification:2370084
- RefSeq identity:NM_002119
- Classification:C1-set domain containing, Histocompatibility complex
- VEGA ID:OTTHUMG00000031211
- Gene symbolPRKDC, HLA-DOA
- isotype filter
- Immunoglobulin G IgG
- LabelHRP
- label filter
- HRP
- technique filter
- Antibody
- dna
- TechniqueAntibody, dna, antibodies against human proteins, antibodies for, antibody Conjugates
- Alternative techniqueantibodies
Gene info
Locus Specific Databases:LRG_162
Gene info
Locus Specific Databases:IMGT/HLA Database