Spoligotyping Membrane

• Catalog number
  IM9702
• Price
  Please ask
• Size
  1 EA

• Availability
  Please contact Gentaur/Genprice to check the latest availability
• Ordering
  Current price is for Diagnostics labs. Special -16% discount for Research Institutes. For ordering please contact us at +32 16 58 90 45
• Technical file
  Please contact us to request the current datasheet or security datasheet
• Description
  Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. 
• Test
  A rapid, polymerase chain reaction (PCR)-based method for genotyping strains of the Mycobacterium tuberculosis complex (MTB). Spoligotyping data can be represented in absolute terms (digitally), and the results can be readily shared among laboratories, thereby enabling the creation of large international databases. Since the spoligotype assay was standardized more than 10 yr. ago, tens of thousands of isolates have been analyzed, giving a global picture of MTB strain diversity. The GENTAUR method is highly reproducible and has been developed into a high-throughput assay for large molecular epidemiology projects. In the United States, spoligotyping is employed on nearly all newly identified culture-positive cases of tuberculosis as part of a national genotyping program. The strengths of this method include its low cost, its digital data results, the good correlation of its results with other genetics markers, its fair level of overall differentiation of strains, its high-throughput capacity, and its ability to provide species information. However, the method's weaknesses include the inability of spoligotyping to differentiate well within large strain families such as the Beijing family, the potential for convergent evolution of patterns, the limited success in improving the assay through expansion, and the difficulty in obtaining the specialized membranes and instrumentation

• Gene target
  Membrane  
• Gene symbol
  PXMP4, PXMP2
• Short name
  Spoligotyping
• Technique
  Spoligotyping, spoligotypings
• Alternative name
  Spoligotyping Membrane
• Alternative technique
  mycobacteria

Gene info

• Identity
  HGNC:15920
• Gene
  PXMP4
• Long gene name
  peroxisomal membrane protein 4
• Synonyms gene name
  • peroxisomal membrane protein 4 (24kD)
  • peroxisomal membrane protein 4, 24kDa
• Synonyms
  • PMP24
• Synonyms name
  • 24 kDa peroxisomal intrinsic membrane protein
• GenBank acession
  • AF072864
• Locus
  20q11.22
• Discovery year
  2001-06-21
• Entrez gene record
  11264
• Pubmed identfication
  • 10366717
• RefSeq identity
  • NM_007238
• Classification
  • Tim17 family
• VEGA ID
  OTTHUMG00000032273

Gene info

• Identity
  HGNC:9716
• Gene
  PXMP2
• Long gene name
  peroxisomal membrane protein 2
• Synonyms gene name
  • peroxisomal membrane protein 2 (22kD)
  • peroxisomal membrane protein 2, 22kDa
• Synonyms
  • PMP22
  • MPV17L3
• Locus
  12q24.33
• Discovery year
  1992-03-03
• Entrez gene record
  5827
• Pubmed identfication
  • 11590176
  • 19352492
• RefSeq identity
  • NM_018663
• VEGA ID
  OTTHUMG00000168019

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