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Sheep anti EBNA 3A

  • Catalog number
    F115P
  • Product name
    Sheep anti EBNA 3A
  • Size
    250 μg
  • Category
    Primary Antibodies
  • Long description
    EBNA-3A is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA-3A functions as a transcriptional regulator though the target genes are currently unknown. Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop
  • Antibody come from
    Recombinant EBNA-3A protein
  • Other description
    Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
  • Clone
    Polyclonal
  • Isotype
    not specified
  • Antigen antibody binding interaction
    Sheep anti EBNA 3A Antibody
  • Antibody is raised in
    Sheep
  • Antibody s reacts with
    N/A
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Label
    unlabeled
  • Antibody s specificity
    No Data Available
  • Application
    Western Blot
  • Antibody s suited for
    Applications: western blotting at 0.25-1.00 µg/ml
  • Storage
    -20ºC
  • Relevant references
    1. Anderton, E., et al, 'Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma' Oncogene 2007, 27, , 421-433_x000B_2. O'Nions, J., et al, 'EpsteinÐBarr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2' Oncogene 2003, 22, , 7181-7191_x000B_3. JimŽnez-Ram’rez, C., et al, 'Epstein-Barr Virus EBNA-3C Is Targeted to and Regulates Expression from the Bidirectional LMP-1/2B Promoter' Journal of Virology 2006, 80, , 11200-11208_x000B_4. Yuan, J., et al, 'Virus and Cell RNAs Expressed during Epstein-Barr Virus Replication' Journal of Virology 2006, 80, , 2548-2565_x000B_5. Hong, G.K., et al, 'Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model' Journal of Virology 2005, 79, , 13993-14003_x000B_6. Rosendorff, A., et al, 'EBNA3C Coactivation with EBNA2 Requires a SUMO Homology Domain' Journal of Virology 2004, 78, , 367-377_x000B_7. Maruo, S., et al, 'Epstein-Barr Virus Nuclear Protein EBNA3A Is Critical for Maintaining Lymphoblastoid Cell Line Growth' Journal of Virology 2003, 77, , 10437-10447_x000B_8. Dalbis-Tran, R., et a, 'Amino Acids of Epstein-Barr Virus Nuclear Antigen 3A Essential for Repression of Jkappa -Mediated Transcription and Their Evolutionary Conservation' Journal of Virology 2001, 75, , 90-99_x000B_9. Sample, J., et al. ÔEpstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes.Õ J. Virol., 64, 4084-4092 (1990)
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Antibody s link
    Antibody_s_link
  • Gene target
    EBNA 3A
  • Host
    Sheep
  • isotype filter
    • not specified
  • Short name
    anti EBNA 3A
  • label filter
    • unlabeled
  • technique filter
    • anti
  • Technique
    anti, antibody to
  • Alternative technique
    antibodies