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Rabbit anti Integrin antibody beta 1 (fibronectin receptor antibody beta polypeptide antibody antigen CD29 includes MDF2 antibody MSK12) (ITGB1)

  • Catalog number
    X2190P
  • Product name
    Rabbit anti Integrin antibody beta 1 (fibronectin receptor antibody beta polypeptide antibody antigen CD29 includes MDF2 antibody MSK12) (ITGB1)
  • Size
    50 μg
  • Category
    Primary Antibodies
  • Long description
    Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
  • Antibody come from
    C-terminal domain of human
  • Other description
    Phosphate buffered saline containing 0.1% sodium azide. Immunoaffinity Purification
  • Clone
    Polyclonal
  • Isotype
    not specified
  • Antigen antibody binding interaction
    Rabbit anti Integrin antibody beta 1 (fibronectin receptor antibody beta polypeptide antibody antigen CD29 includes MDF2 antibody MSK12) (ITGB1) Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Label
    unlabeled
  • Antibody s specificity
    No Data Available
  • Application
    Immunohistochemistry-Paraffin
  • Antibody s suited for
    Optimal concentration should be evaluated by serial dilutions.
  • Storage
    Long term: -70ºC; Short term: +4ºC
  • Relevant references
    no information yet
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Antibody s link
    Antibody_s_link
  • Alternative to gene target
    • [ "integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)", "CD29 and FNRB and GPIIA and MDF2 and MSK12 and VLA-BETA and VLAB", "ITGB1 and IDBG-68302 and ENSG00000150093 and 3688", "alpha-actinin binding", "Cell surfaces", "Itgb1 and IDBG-201159 and ENSMUSG00000025809 and 16412", "ITGB1 and IDBG-637396 and ENSBTAG00000015910 and 281876" ]
  • Gene target
    Integrin beta 1 fibronectin receptor beta polypeptide CD29 includes MDF2 MSK12 ITGB1
    • Gene info
    Gene info
    • Identity:HGNC:53718
    • Gene:ITGB1-DT
    • Long gene name:ITGB1 divergent transcript
    • Discovery year:2017-09-01
    • Entrez gene record:101929475
    • Classification:Divergent transcripts
    Gene info
  • Gene symbol
    ITGB1, ITGB1-DT, IATPR
  • Host
    Rabbit, Rabbits
  • isotype filter
    • not specified
  • Short name
    Rabbit anti Integrin antibody beta 1 (fibronectin receptor antibody beta polypeptide antibody antigen CD29 includes MDF2 antibody MSK12) (ITGB1)
  • label filter
    • unlabeled
  • technique filter
    • Antibody
    • antigen
    • Rabbit
    • anti
  • Technique
    Antibody, antigen, Rabbit, anti, antibody to, antibodies against human proteins, antibodies for, antigenes
  • Alternative technique
    antibodies, antigenes, rabbit-anti