- Catalog numberX2160P
- Product nameRabbit anti Ceramide kinase (CERK) (IN)
- Size10MinibLots
- PriceAsk For Price
- CategoryPrimary Antibodies
- Long descriptionSphingolipids, in addition to being structural components of membranes, regulate cell-cell and cell-substrate interactions, proliferation, and differentiation. Members of this diverse group of lipids have emerged as a novel class of signaling molecules that also regulate phagocytosis. The mechanisms by which sphingolipids exert these effects remain incompletely defined. More than a decade ago, it was found that ceramide can be phosphorylated to ceramide 1-phosphate (C1P). Ceramide kinase (CERK) and its phosphorylated product ceramide 1-phosphate (C1P) are central players in inflammation and cancer. The product of CERK activity, ceramide 1-phosphate (C1P), has been reported to have mitogenic effects. C1P is a direct activator of cytosolic phospholipase A2 and is involved in arachidonic acid release. CERK is a mediator of Ca2+-dependent degranulation in mast cells. In both arachidonic acid release and mast cell degranulation, the intracellular elevation of Ca2+ is a central event that acts as a regulatory mechanism of CERK activity. C1P is found in brain synaptic vesicles, and plays a role in regulating the secretion of neurotransmitters. CERK activity exists in HL-60 cells where the C1P is derived from ceramide released from sphingomyelin. The expressed kinase has specific ceramide phosphorylating activity. CERKs exist in a variety of cellular organisms, including plants, nematodes, insects, and vertebrates.
- Antibody come frominternal domain of human
- Other descriptionPhosphate buffered saline containing 0.1% sodium azide. Immunoaffinity Purification
- ClonePolyclonal
- Isotypenot specified
- Antigen antibody binding interactionRabbit anti Ceramide kinase (CERK) (IN) Antibody
- Antibody is raised inRabbit
- Antibody s reacts withHuman
- Antibody s reacts with these speciesThis antibody doesn't cross react with other species
- Labelunlabeled
- Antibody s specificityNo Data Available
- ApplicationImmunohistochemistry
- Antibody s suited forOptimal concentration should be evaluated by serial dilutions. ( WrkConcMin: 10 µg/ml)
- StorageLong term: -70ºC; Short term: +4ºC
- Relevant referencesno information yet
- Protein numbersee ncbi
- WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
- Antibody s link
- Alternative to gene target
- [ "ceramide kinase", "CERK and IDBG-12219 and ENSG00000100422 and 64781", "ATP binding", "Plasma membranes", "Cerk and IDBG-171293 and ENSMUSG00000035891 and 223753", "CERK and IDBG-642451 and ENSBTAG00000046654 and" ]
- Gene targetCeramide kinase CERK IN
- Gene symbolCERK
- HostRabbit, Rabbits
- isotype filter
- not specified
- Short nameRabbit anti Ceramide kinase (CERK) (IN)
- label filter
- unlabeled
- technique filter
- Rabbit
- anti
- TechniqueRabbit, anti, antibody to
- Alternative techniquerabbit-anti, antibodies