- Catalog numberX2046M
- Product nameMouse anti Cytochrome P450 1A2
- Size200 μg
- PriceAsk For Price
- CategoryPrimary Antibodies
- Long descriptionP450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. NADPH cytochrome 450 reductase is a microsomal enzyme responsible for the transfer of electrons from NADPH to cytochrome P450 enzymes during the P450 catalytic cycle. NADPH cytochrome P450 reductase is localized to the endoplasmic reticulum where it is also able to transfer electrons to heme oxygenase and cytochrome 5. NADPH cytochrome P450 reductase is structurally related to two separate flavoprotein families, ferredoxin nucleotide reductase (FNR) and flavodoxin. Electron transfer of NADPH cytochrome P450 reductase requires the binding of two flavin cofactors, FAD and FMN, to the FNR and flavodoxin domains, respectively.
- Antibody come fromHybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the human ATIC protein and mouse myeloma Ag8563 cells. Sequence common in frog, fruit fly, rat and mouse.
- Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
- Clone3B8C1
- IsotypeIgG1
- Antigen antibody binding interactionMouse anti Cytochrome P450 1A2 Antibody
- Antibody is raised inMouse
- Antibody s reacts withHuman, Rat
- Antibody s reacts with these speciesThis antibody doesn't cross react with other species
- Labelunlabeled
- Antibody s specificityNo Data Available
- ApplicationWestern Blot, Immunohistochemistry
- Antibody s suited forAntibody can be used for Western blotting (1-2 µg/ml) and immunohistochemistry on formalin-fixed, paraffin-embedded tissues (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
- Storage-20ºC
- Relevant references1. Bulock, K.G., et al. (2002). The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J. Biol. Chem. 277(25):22168-22174._x000B__x000B_2. Marie, S., et al. (2004). AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Am. J. Hum. Genet. 74(6):1276-1281.
- Protein numbersee ncbi
- WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
- Antibody s link
- Gene targetCytochrome P450 1A2
- Identity:HGNC:2640
- Gene:CYP3A7
- Long gene name:cytochrome P450 family 3 subfamily A member 7
- Synonyms gene name:cytochrome P450, subfamily IIIA, polypeptide 7, cytochrome P450, family 3, subfamily A, polypeptide 7
- Synonyms:CP37, P450-HFLA
- Discovery year:1992-09-14
- Entrez gene record:1551
- Pubmed identification:2722762
- Classification:Cytochrome P450 family 3
- VEGA ID:OTTHUMG00000156726
- Identity:HGNC:2602
- Gene:CYP24A1
- Long gene name:cytochrome P450 family 24 subfamily A member 1
- Synonyms gene name:cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase), cytochrome P450, family 24, subfamily A, polypeptide 1
- Synonyms:CP24, P450-CC24
- Discovery year:1992-09-09
- Entrez gene record:1591
- Classification:Cytochrome P450 family 24
- VEGA ID:OTTHUMG00000032773
- Identity:HGNC:2595
- Gene:CYP1A1
- Long gene name:cytochrome P450 family 1 subfamily A member 1
- Synonyms gene name:cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450, family 1, subfamily A, polypeptide 1
- Synonyms:P450DX, P1-450P450-CCP11
- Discovery year:1986-01-01
- Entrez gene record:1543
- Pubmed identification:15128046
- RefSeq identity:NM_000499
- Classification:Cytochrome P450 family 1
- VEGA ID:OTTHUMG00000142812
- Identity:HGNC:2649
- Gene:CYP51A1
- Long gene name:cytochrome P450 family 51 subfamily A member 1
- Synonyms gene name:cytochrome P450, 51 (lanosterol 14-alpha-demethylase), cytochrome P450, family 51, subfamily A, polypeptide 1
- Synonyms:CP51, CYPL1P450L1LDMP450-14DM
- Discovery year:1996-10-26
- Entrez gene record:1595
- Pubmed identification:8975714
- Classification:Cytochrome P450 family 51
- VEGA ID:OTTHUMG00000131131
- Identity:HGNC:2625
- Gene:CYP2D6
- Long gene name:cytochrome P450 family 2 subfamily D member 6
- Synonyms gene name:cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6, cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2, cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2, cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2, cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2, cytochrome P450, family 2, subfamily D, polypeptide 6
- Synonyms:CPD6, P450-DB1, CYP2D, P450C2D,
- Discovery year:1992-04-07
- Entrez gene record:1565
- Pubmed identification:8449513
- Classification:Cytochrome P450 family 2
- VEGA ID:OTTHUMG00000150918
- Gene symbolCYP3A7, CYP24A1, CYP1A1, CYP51A1, CYP2D6
- Hostmouse
- isotype filter
- IgG1
- Short nameMouse anti Cytochrome P450 1A2
- label filter
- unlabeled
- technique filter
- Mouse
- anti
- TechniqueMouse, anti, antibody to, mouses
- Alternative techniquemurine, antibodies
Gene info
Locus Specific Databases:PharmVar Human Cytochrome P450 (CYP) Allele Nomenclature
Gene info
Gene info
Locus Specific Databases:PharmVar Human Cytochrome P450 (CYP) Allele NomenclatureLRG_1262