- Catalog numberF40069-0.4ML
- Product namePhospho-p21 Antibody (pS78)
- Size0.4 ml
- PriceAsk For Price
- Short nameAnti-Phospho-p21 (pS78)
- CategoryAntibody
- ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
- FormAntigen affinity purified
- ConjugationUnconjugated
- ClonePolyclonal antibody
- Recognised antigenPhospho-p21 (pS78)
- Host animalRabbit (Oryctolagus cuniculus)
- ClonalityPolyclonal (rabbit origin)
- IsotypeRabbit Ig
- Species reactivityMouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
- Tested applicationsDB, ELISA
- Recommended dilutionsDot blot: 1:500
- NotesTitration of the phospho-p21 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
- Intented useThis phospho-p21 antibodyis to be used only for research purposes and not for diagnostics..
- UniprotP39689
- PurityAntigen affinity
- DescriptionThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
- ImmunogenThis phospho-p21 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS78 of mouse p21Cip1.
- StorageAliquot the phospho-p21 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
- Gene targetPhospho-p21 pS78
- isotype filter
- Rabbit Ig
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies