- Catalog numberR30232
- Product nameMorg1 Antibody
- Size0.1mg
- PriceAsk For Price
- Short nameAnti-Morg1
- CategoryAntibody
- Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
- FormAntigen affinity purified
- ConjugationUnconjugated
- ClonePolyclonal antibody
- Recognised antigenMorg1
- Host animalRabbit (Oryctolagus cuniculus)
- ClonalityPolyclonal (rabbit origin)
- IsotypeRabbit IgG
- Species reactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
- Tested applicationsWB, IHC-P
- Recommended dilutionsWestern blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
- NotesThe stated application concentrations are suggested starting amounts. Titration of the Morg1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
- Intented useThis Morg1 antibodyis to be used only for research purposes and not for diagnostics..
- UniprotQ9BRX9
- PurityAntigen affinity
- DescriptionMORG1(mitogen-activated protein kinase organizer 1), a member of the WD-40 protein family that was isolated as a binding partner of the extracellular signal-regulated kinase(ERK) pathway scaffold protein MP1. MORG1 specifically associates with several components of the ERK pathway, including MP1, Raf-1, MEK, and ERK, and stabilizes their assembly into an oligomeric complex. MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor. Suppression of MORG1 by short interfering RNA leads to a marked reduction in ERK activity when cells are stimulated with serum. MORG1 is a component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling.
- ImmunogenAn amino acid sequence from the N-terminus of human Morg1 (RAVRFNVDGNYCLTC) was used as the immunogen for this Morg1 antibody.
- StorageAfter reconstitution, the Morg1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
- Gene targetMorg1
- Identity:HGNC:32672
- Gene:WDR83
- Long gene name:WD repeat domain 83
- Synonyms:MORG1
- Discovery year:2010-01-25
- Entrez gene record:84292
- Pubmed identification:15118098, 16407229
- RefSeq identity:NM_032332
- Classification:Spliceosomal P complex, Spliceosomal C complex, WD repeat domain containing
- VEGA ID:OTTHUMG00000169356
- Gene symbolWDR83
- isotype filter
- Rabbit IgG
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies