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GNAS Antibody

  • Catalog number
    F40026-0.4ML
  • Product name
    GNAS Antibody
  • Size
    0.4 ml
  • Price
    Ask For Price
  • Contact us
    GNAS Antibody
  • Short name
    Anti-GNAS
  • Category
    Antibody
  • Concentration
    In 1X PBS, pH 7.4, with 0.09% sodium azide
  • Form
    Antigen affinity purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    GNAS
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Isotype
    Rabbit Ig
  • Species reactivity
    Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB, IHC, IF, FACS, ELISA
  • Recommended dilutions
    Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
  • Notes
    Titration of the GNAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This GNAS antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    Q5FWY2
  • Purity
    Antigen affinity
  • Description
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
  • Immunogen
    A portion of amino acids 287-315 from the human protein was used as the immunogen for this GNAS antibody.
  • Storage
    Aliquot the GNAS antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
  • Gene target
    GNAS
    • Gene info
    Locus Specific Databases:LRG_1051
    Gene info
    Locus Specific Databases:LOVD - Leiden Open Variation Database
  • Gene symbol
    GNAS-AS1, GNAS
  • isotype filter
    • Rabbit Ig
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies