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GBP1 Antibody

  • Catalog number
    R30626
  • Product name
    GBP1 Antibody
  • Size
    0.1mg
  • Price
    Ask For Price
  • Contact us
    GBP1 Antibody
  • Short name
    Anti-GBP1
  • Category
    Antibody
  • Concentration
    0.5mg/ml if reconstituted with 0.2ml sterile DI water
  • Form
    Antigen affinity purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    GBP1
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Isotype
    Rabbit IgG
  • Species reactivity
    Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB
  • Recommended dilutions
    Western blot: 0.5-1ug/ml
  • Notes
    The stated application concentrations are suggested starting amounts. Titration of the GBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This GBP1 antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    P32455
  • Purity
    Antigen affinity
  • Description
    Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of two binding motifs rather than three. The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, respectively. All GBPs have a conserved N-terminal globular GTP-binding domain containing two consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene localizes to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B.
  • Immunogen
    Amino acids 566-589 (QKESRIMKNEIQDLQTKMRRRKAC-human) were used as the immunogen for this GBP1 antibody.
  • Storage
    After reconstitution, the GBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
  • Alternative to gene target
    • [ "guanylate binding protein 1, interferon-inducible", "GBP1 and IDBG-100165 and ENSG00000117228 and 2633", "identical protein binding", "Extracellular" ]
  • Gene target
    GBP1
    • Gene info
  • Gene symbol
    GBP1
  • isotype filter
    • Rabbit IgG
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies