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DR3 Antibody (Death Receptor 3)

  • Catalog number
    F45569-0.4ML
  • Product name
    DR3 Antibody (Death Receptor 3)
  • Size
    0.4 ml
  • Short name
    Anti-DR3 (Death Receptor 3)
  • Category
    Antibody
  • Concentration
    In 1X PBS, pH 7.4, with 0.09% sodium azide
  • Form
    Antigen affinity purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    DR3 (Death Receptor 3)
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Isotype
    Rabbit Ig
  • Species reactivity
    Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB, ELISA
  • Recommended dilutions
    Western blot: 1:1000
  • Notes
    Titration of the DR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This DR3 antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    Q93038
  • Purity
    Antigen affinity
  • Description
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
  • Immunogen
    A portion of amino acids 214-242 from the human protein was used as the immunogen for this DR3 antibody.
  • Storage
    Aliquot the DR3 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
  • Gene target
    DR3 Death Receptor 3
    • Gene info
  • Gene symbol
    TNFRSF25
  • isotype filter
    • Rabbit Ig
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies