gentaur logogentaur logo
x

CSB Antibody / Cockayne Syndrome B / ERCC6

  • Catalog number
    R32528
  • Product name
    CSB Antibody / Cockayne Syndrome B / ERCC6
  • Size
    0.1mg
  • Short name
    Anti- CSB / Cockayne Syndrome B / ERCC6
  • Category
    Antibody
  • Concentration
    0.5mg/ml if reconstituted with 0.2ml sterile DI water
  • Form
    Antigen affinity purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    CSB / Cockayne Syndrome B / ERCC6
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Isotype
    Rabbit IgG
  • Species reactivity
    Human (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB
  • Recommended dilutions
    Western blot: 0.5-1ug/ml
  • Added buffer
    Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2.5% BSA and 0.025% sodium azide
  • Intented use
    This CSB antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    Q03468
  • Purity
    Antigen affinity
  • Description
    DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.
  • Immunogen
    Amino acids 160-205 (QAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVK) from the human protein were used as the immunogen for the CSB antibody.
  • Storage
    After reconstitution, the CSB antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
  • Localization
    Nuclear
  • Alternative to gene target
    • [ "excision repair cross-complementing rodent repair deficiency, complementation group 6", "ARMD5 and CKN2 and COFS and COFS1 and CSB and RAD26 and UVSS1", "ERCC6 and IDBG-304121 and ENSG00000225830 and 2074", "protein N-terminus binding", "nuclei", "Ercc6 and IDBG-147857 and ENSMUSG00000054051 and 319955", "ERCC6 and IDBG-631777 and ENSBTAG00000032527 and 522908" ]
  • Gene target
    CSB / Cockayne Syndrome B / ERCC6
    • Gene info
    Locus Specific Databases:LRG_465
    Gene info
    Gene info
    Gene info
    Gene info
  • Gene symbol
    ERCC6, MT-CSB1, MT-CSB3, MT-CSB2, CSH2
  • isotype filter
    • Rabbit IgG
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies
  • Disease
    syndrome
  • disease filter
    • syndrome