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SHEEP ANTI HUMAN ERYTHROPOIETIN RECEPTOR

  • Catalog number
    MBS224081
  • Product name
    SHEEP ANTI HUMAN ERYTHROPOIETIN RECEPTOR
  • Size
    5x0.1 mg
  • Products type
    Antibody
  • Products short name
    [ERYTHROPOIETIN RECEPTOR]
  • Other names
    [erythropoietin receptor; Erythropoietin receptor; erythropoietin receptor; erythropoietin receptor]
  • Other gene names
    [EPOR; EPOR; EPO-R; EPO-R]
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Host
    Sheep
  • Reactivity
    Mouse
  • Specificity
    This item recognises Erythropoietin Receptor (EPOR), a type I transmembrane protein and member of the type I cytokine receptor family, expressed by erythroid cells and erythroid progenitor cells, which acts as a receptor for erythropoietin (EPO) to mediate erythroblast proliferation and differentiation, and maintain progenitor survival. Binding of EPO to EPOR, results in the dimerization of the EPOR and the triggering of the JAK2/STAT5 signaling cascade, and in some cell types activation of STAT1 and STAT3. Several isoforms of EPOR exist: EPOR-F, EPOR-S and EPOR-T, and a functional EPOR is found on endothelial cells and cardiomyocytes within the cardiovascular system, suggesting a role in cardiac function. This item has been shown to block Iodine125 labelled erythropoietin ligand binding using erythroleukemia cell line TF-1 with 3000 EPOR/cell in neutralization studies, see Harris, K.W.et al. for details.This item is reported as suitable for use in immunocytochemistry.This item has been reported for use in functional studies. Removal of Sodium Azide is recommended prior to use in functional assays. The recommended concentration for functional assays is 500ug/ml.
  • Form
    Purified Purified IgG - liquid
  • Concentration
    IgG concentration 1.0mg/ml
  • Storage stability
    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
  • Tested application
    ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
  • Gene target
    ERYTHROPOIETIN RECEPTOR
    • Gene info
    • Identity:HGNC:3416
    • Gene:EPOR
    • Long gene name:erythropoietin receptor
    • Discovery year:1990-05-14
    • Entrez gene record:2057
    • Classification:Fibronectin type III domain containing
    • VEGA ID:OTTHUMG00000182027
  • Gene symbol
    EPOR
  • isotype filter
    • IgG
  • Short name
    ANTI ERYTHROPOIETIN RECEPTOR
  • technique filter
    • anti human
    • anti
  • Technique
    anti human, anti, antibody to, anti human antibodies
  • Alternative technique
    antibodies