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p53 Tumor Suppressor Protein Mouse Monoclonal Antibody

  • Catalog number
    MBS438061
  • Product name
    p53 Tumor Suppressor Protein Mouse Monoclonal Antibody
  • Size
    0.1 mg (With BSA & Azide at 0.2mg/mL)
  • Products type
    Antibody
  • Products short name
    [p53 Tumor Suppressor Protein]
  • Products name syn
    [Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53]
  • Other names
    [cellular tumor antigen p53 isoform a; Cellular tumor antigen p53; cellular tumor antigen p53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53]
  • Products gene name
    [TP53]
  • Other gene names
    [TP53; TP53; P53; BCC7; LFS1; TRP53; P53]
  • Clonality
    Monoclonal
  • Isotype
    IgG2a
  • Clone
    [SPM589]
  • Host
    Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
  • Reactivity
    Human. Does not react with Mouse and Rat
  • Specificity
    Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
  • Form
    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  • Storage stability
    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • Tested application
    Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
  • Gene target
    p53 Tumor Suppressor Protein Monoclonal
  • isotype filter
    • IgG2a
  • Short name
    p53 Tumor Suppressor Protein Mouse Monoclonal Antibody
  • technique filter
    • Mouse monoclonal
    • Antibody
    • Mouse
  • Technique
    Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
  • Alternative technique
    antibodies, murine
  • Tissue
    tumor
  • tissue filter
    • tumor