NFkB Activating Kinase, active, Recombinant, Human (Nuclear Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1)

• Catalog number
  MBS636289
• Price
  949.43 USD
• Size
  0.01 mg

• Products_type
  Active Protein
• Products_short_name
  [NFkB Activating Kinase, active]
• Purity
  PurifiedPurified using Ni2+/NTA agarose. ~42% by SDS PAGE and Coomassie blue staining.
• Form
  Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 300mM sodium chloride, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF and 0.1% 2-mercaptoethanol.
• Storage_stability
  For long-term storage, store at -70 degree C. Aliquots are stable for at least 6 months at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Gene
  NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  NFkB   Activating   Kinase   active   Factor   kappa   TANK-Binding   Kinase   NAK   TBK1  
• Gene symbol
  TBK1, TANK-AS1, TANK, NR4A1
• Short name
  NFkB Activating Kinase, active, Recombinant, ( Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  Sf21 cells
• Species
  Human, Humans
• Alternative name
  NFkB Activating phosphorylation catalyst, functionnal, Rec., H. sapiens (Nuclear Factor kappa B, TANK-Binding phosphorylation catalyst 1, NAK, TANK-binding kinase 1)
• Alternative technique
  rec
• Alternative to gene target
  TANK-binding kinase 1, TBK1 and IDBG-44993 and ENSG00000183735 and 29110, transferase activity, Cytoplasm, Tbk1 and IDBG-192882 and ENSMUSG00000020115 and 56480, TBK1 and IDBG-634420 and ENSBTAG00000017401 and 533141

Gene info

• Identity
  HGNC:11584
• Gene
  TBK1
• Long gene name
  TANK binding kinase 1
• Synonyms gene name
  • TANK-binding kinase 1
• Synonyms
  • NAK
• GenBank acession
  • AF191838
• Locus
  12q14.2
• Discovery year
  2000-06-08
• Entrez gene record
  29110
• Pubmed identfication
  • 10581243
  • 10783893
• RefSeq identity
  • NM_013254
• Classification
  • I kappa B kinases
• VEGA ID
  OTTHUMG00000168796
• Locus Specific Databases
  • LRG_1306

Gene info

• Identity
  HGNC:40575
• Gene
  TANK-AS1
• Long gene name
  TANK antisense RNA 1
• Locus
  2q24.2
• Discovery year
  2020-03-27
• Entrez gene record
  105373719
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:11562
• Gene
  TANK
• Long gene name
  TRAF family member associated NFKB activator
• Synonyms gene
  • TRAF2
• Synonyms gene name
  • TRAF family member-associated NFKB activator
• Synonyms
  • I-TRAF
• GenBank acession
  • U59863
• Locus
  2q24.2
• Discovery year
  1997-06-12
• Entrez gene record
  10010
• Pubmed identfication
  • 8710854
  • 8855313
• RefSeq identity
  • NM_133484
• VEGA ID
  OTTHUMG00000132037

Gene info

• Identity
  HGNC:7980
• Gene
  NR4A1
• Long gene name
  nuclear receptor subfamily 4 group A member 1
• Synonyms gene
  • HMR
  • GFRP1
• Synonyms gene name
  • nuclear receptor subfamily 4, group A, member 1
• Synonyms
  • TR3
  • N10
  • NAK-1
  • NGFIB
  • NUR77
• GenBank acession
  • L13740
• Locus
  12q13.13
• Discovery year
  1990-09-10
• Entrez gene record
  3164
• Pubmed identfication
  • 2626032
• Classification
  • Nuclear receptor subfamily 4 group A
• VEGA ID
  OTTHUMG00000150393

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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