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Mouse Anti-Human TLR4-UNLB

  • Catalog number
    MBS670142
  • Product name
    Mouse Anti-Human TLR4-UNLB
  • Size
    0.1 mg
  • Products type
    Antibody
  • Products short name
    [Toll-like Receptor 4 (TLR4)]
  • Products name syn
    [Mouse Anti-Human TLR4 - Purified, Unlabeled Antibody; Mouse Anti-Human Toll-like Receptor 4 (TLR4)]
  • Other names
    [toll-like receptor 4; Toll-like receptor 4; toll-like receptor 4; OTTHUMP00000022807; homolog of Drosophila toll; toll-like receptor 4; hToll]
  • Other gene names
    [TLR4; TLR4; TOLL; CD284; hToll; ARMD10]
  • Clonality
    Monoclonal
  • Isotype
    Mouse IgG2a
  • Clone
    [1E11]
  • Host
    Mouse
  • Reactivity
    Human
  • Specificity
    Human Toll-like Receptor 4 (TLR4) The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLR4 is involved in the recognition of lipopolysaccharide (LPS), an abundant glycolipid of Gram-negative bacteria. Through its association with MD-2 and CD14, TLR4 recognizes and initiates multiple intracellular signaling events such as the activation of NF- kappa B leading to the ultimate synthesis and release of a number of proinflammatory mediators including interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor- alpha (TNF- alpha). TLR4 has also been associated in the recognition of and lipocheic acid (LTA), Hsp60 and Hsp70.1-10
  • Form
    Purified (UNLB) Antibody
  • Storage stability
    The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. Reagents are stable for the period shown on the label if stored as directed.
  • Tested application
    ELISA; Western Blot
  • Alternative to gene target
    • [ "toll-like receptor 4", "ARMD10 and CD284 and TLR-4 and TOLL", "TLR4 and IDBG-82738 and ENSG00000136869 and 7099", "protein binding", "Cell surfaces", "Tlr4 and IDBG-156729 and ENSMUSG00000039005 and 21898", "TLR4 and IDBG-638758 and ENSBTAG00000006240 and 281536" ]
  • Gene target
    TLR4-UNLB
    • Gene info
    Locus Specific Databases:LRG_320
  • Gene symbol
    TLR4
  • isotype filter
    • Mouse IgG2a
  • Short name
    Mouse Anti- TLR4-UNLB
  • technique filter
    • anti-Human
    • anti-
    • Mouse
    • anti
  • Technique
    anti-Human, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, mouses
  • Alternative technique
    murine, antibodies