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MOUSE ANTI HUMAN CA125

  • Catalog number
    MBS214597
  • Product name
    MOUSE ANTI HUMAN CA125
  • Size
    0.2 mg
  • Products type
    Antibody
  • Products short name
    [CA125]
  • Products name syn
    [MUCIN 16]
  • Other names
    [mucin-16; Mucin-16; mucin-16; CA125 ovarian cancer antigen; ovarian cancer-related tumor marker CA125; ovarian carcinoma antigen CA125; mucin 16, cell surface associated; Ovarian cancer-related tumor marker CA125; CA-125; Ovarian carcinoma antigen CA125]
  • Products gene name
    [CA125]
  • Other gene names
    [MUC16; MUC16; CA125; CA125; MUC-16; CA-125]
  • Clonality
    Monoclonal
  • Isotype
    IgG1
  • Clone
    [X75]
  • Host
    Mouse
  • Reactivity
    Human
  • Specificity
    Mouse anti Human CA125 antibody, clone X75 recognizes the ovarian cancer mucin CA125 (also known as MUCIN 16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number of 156-amino acid repeat units, over 60 in all. These repeats are known to bind the antibodies OC125 and M-11. CA125 is present within normal ovarian, endometrium, endocervix and fallopian tissue, but levels are elevated in over 90% of women with advanced ovarian cancer. CA125 levels may also be elevated in other cancers and non-cancerous conditions such as peritonitis, endometriosis and liver cirrhosis. Levels may also fluctuate during the menstrual cycle and occasionally increases in pregnancy, making CA125 an unreliable marker for ovarian cancer in premenopausal women. The function of CA125 in healthy tissue is unknown but it is thought to provide a protective lubricating barrier against particles and infectious agents at mucosal surfaces. CA125 was concluded by the International Society of Oncology and BioMarkers (ISOBM) to contain two major antigenic domains. Mouse anti Human CA125 antibody, clone X75 recognizes the epitope specificity group B, similar to the M-11 antibody (Nustad et al. 2002). Mouse anti Human CA125 antibody, clone X75 has been used successfully as both a capture and detection reagent in the development of sensitive ELISA assays for the measurement of CA125 antigen in human plasma samples.
  • Purity
    Purified IgG prepared by ion exchange chromatography
  • Form
    Purified IgG - liquid
  • Concentration
    IgG concentration 1.0mg/ml
  • Storage stability
    Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
  • Tested application
    ELISA, Western Blot (WB)
  • Gene target
    CA125
    • Gene info
    Gene info
  • Gene symbol
    MUC16, NBR1
  • isotype filter
    • IgG1
  • Short name
    MOUSE ANTI CA125
  • technique filter
    • anti human
    • Mouse
    • anti
  • Technique
    anti human, Mouse, anti, antibody to, anti human antibodies, mouses
  • Alternative technique
    murine, antibodies