- Catalog numberbs-6428R-A647
- Product namePPP4C Antibody, ALEXA FLUOR 647
- Size100ul
- PriceAsk For Price
- Short nameAnti-PPP4C
- Long namePPP4C Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
- Also known asAnti-PPP4C PAb ALEXA FLUOR 647
- CategoryConjugated Primary Antibodies
- Conjugated withALEXA FLUOR® 647
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenPPP4C
- SpecificityThis is a highly specific antibody against PPP4C.
- ModificationUnmodified
- Modification SiteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PPP4C
- Gene ID Number5531
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman, Mouse, Rat
- Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the antigenProtein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
- PurificationPurified by Protein A.
- Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
- Excitation emission650nm/665nm
- SynonymsPP X; PP4C; Protein phosphatase X; PP-X; PP4; PP4C; PP4C_HUMAN; PPH3; PPP4; ppp4c; PPX; protein phosphatase 4 formerly X, catalytic subunit; Protein phosphatase 4 catalytic subunit; Protein phosphatase X; protein phosphatase X, catalytic subunit; Serine/threonine protein phosphatase 4 catalytic subunit; Serine/threonine-protein phosphatase 4 catalytic subunit.
- Gene targetPPP4C
- Identity:HGNC:9319
- Gene:PPP4C
- Long gene name:protein phosphatase 4 catalytic subunit
- Synonyms gene name:protein phosphatase 4 (formerly X), catalytic subunit, protein phosphatase 4, catalytic subunit
- Synonyms:PP4, PPX
- Discovery year:1993-01-22
- Entrez gene record:5531
- Pubmed identification:9177794
- RefSeq identity:NM_002720
- Classification:Protein phosphatase catalytic subunits
- VEGA ID:OTTHUMG00000132113
- Gene symbolPPP4C
- isotype filter
- Immunoglobulin G IgG
- LabelALEXA FLUOR 647
- label filter
- ALEXA FLUOR 647
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies