- Catalog numberCSB-PA026233HD01HU_50ug
- Product nameRabbit Anti Human XRCC5 Antibody-Biotin
- Size50ug
- PriceAsk For Price
- Long nameRabbit Antibody against Human XRCC5, Biotin
- Short nameAnti-XRCC5
- Synonym nameXRCC5 Human Antibody
- HostRabbit, Rabbits
- Species reactivityHuman
- Tested applications recommended dilutionsELISA
- ConjugationBiotin
- Antibody isotypeIgG
- UniProt IDP13010
- FormatLiquid, diluted in buffer
- Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Purity>95%
- Purification methodProtein G purified
- Antibody categoryPolyclonal Antibodies
- Immunogen typeRecombinant Human X-ray repair cross-complementing protein 5 protein (251-455AA)
- Immunogen speciesHuman
- AliasX-ray repair cross-complementing protein 5,86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTC85,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining),XRCC5,G22P2
- BackgroundSingle-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488).
- ClonalityPolyclonal antibody
- Shipping and storageXRCC5 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
- Short name of the antigenX-ray repair cross-complementing protein 5
- Alternative to gene target
- [ "X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)", "KARP-1 and KARP1 and KU80 and Ku86 and KUB2 and NFIV", "XRCC5 and IDBG-80616 and ENSG00000079246 and 7520", "hydrolase activity", "nuclei", "Xrcc5 and IDBG-165686 and ENSMUSG00000026187 and 22596", "BT.88138 and IDBG-643715 and ENSBTAG00000010426 and 531945" ]
- Gene targetXRCC5 -
- Identity:HGNC:12833
- Gene:XRCC5
- Long gene name:X-ray repair cross complementing 5
- Synonyms gene name:X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD)
- Synonyms:KU80KARP-1Ku86KUB2
- Discovery year:1992-01-22
- Entrez gene record:7520
- Pubmed identification:9636207, 9214634
- RefSeq identity:NM_021141
- VEGA ID:OTTHUMG00000133059
- Gene symbolXRCC5
- LabelBiotin
- label filter
- Biotin
- technique filter
- anti human
- Antibody
- Rabbit
- anti
- Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies, rabbit-anti