- Catalog numberMBS438470
- Product nameDOG-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor Marker) Mouse Monoclonal Antibody
- Size5x0.1 mg (With BSA & Azide at 0.2mg/mL)
- PriceAsk For Price
- Products typeAntibody
- Products short name[DOG-1 / TMEM16A / ANO1]
- Products name syn[Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1,TAOS2, ORAOV2, TMEM16A]
- Other names[anoctamin-1; Anoctamin-1; anoctamin-1; anoctamin 1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2]
- Products gene name[TMEM16A]
- Other gene names[ANO1; ANO1; DOG1; TAOS2; ORAOV2; TMEM16A; DOG1; ORAOV2; TAOS2; TMEM16A]
- ClonalityMonoclonal
- IsotypeIgG
- Clone[DG1/447 + DOG-1.1]
- HostMouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
- ReactivityHuman
- SpecificityExpression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
- Form200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Storage stabilityAntibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Tested applicationFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
- Gene target1 / TMEM16A / ANO1 Gastrointestinal Stromal Tumor Monoclonal
- Identity:HGNC:21625
- Gene:ANO1
- Long gene name:anoctamin 1
- Synonyms gene name:oral cancer overexpressed 2, transmembrane protein 16A, anoctamin 1, calcium activated chloride channel
- Synonyms:TAOS2, FLJ10261, DOG1
- Discovery year:2003-10-16
- Entrez gene record:55107
- Pubmed identification:15067359, 18724360, 24692353
- RefSeq identity:NM_018043
- Classification:Anoctamins
- VEGA ID:OTTHUMG00000167204
- Identity:HGNC:40016
- Gene:ANO1-AS1
- Long gene name:ANO1 antisense RNA 1
- Synonyms gene name:ANO1 antisense RNA 1 (non-protein coding)
- Discovery year:2011-04-28
- Classification:Antisense RNAs
- VEGA ID:OTTHUMG00000167205
- Identity:HGNC:33275
- Gene:LINC02584
- Long gene name:long intergenic non-protein coding RNA 2584
- Synonyms gene name:chromosome 11 open reading frame 78, non-protein coding RNA 224, ANO1 antisense RNA 2 (non-protein coding), ANO1 antisense RNA 2, ANO1 antisense RNA 2 (head to head)
- Discovery year:2007-01-29
- Entrez gene record:100009613
- RefSeq identity:NR_103835
- Classification:Long intergenic non-protein coding RNAs
- VEGA ID:OTTHUMG00000167162
- Gene symbolANO1, ANO1-AS1, LINC02584
- isotype filter
- IgG
- Short name-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor ) Mouse Monoclonal Antibody
- technique filter
- Mouse monoclonal
- Antibody
- Mouse
- TechniqueMouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
- Alternative techniqueantibodies, murine
- Tissuetumor
- tissue filter
- tumor