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Products_type
Antibody
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Products_short_name
[CD89]
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Products_name_syn
[Anti -CD89 (CD89 Antigen, FCAR, Immunoglobulin alpha Fc Receptor, IgA Fc Receptor) (FITC)]
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Clonality
Monoclonal
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Clone
[MIP8a]
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Reactivity
Human
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Specificity
Recognises human CD89, a 50-75kD cell surface glycoprotein. Expressed by peripheral blood monocytes and neutrophils. Blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes.
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Purity
Purified Purified
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Form
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
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Storage_stability
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
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Tested_application
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
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Description
The CD89 (CD89 Antigen, FCAR, Immunoglobulin alpha Fc Receptor, IgA Fc Receptor) (FITC) is a α- or alpha protein sometimes glycoprotein present in blood. Antigens are peptides or recombinant or native dependent on the production method. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Properties
This MyBioSource Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. MyBioSource FITC is highly sensitive to pH extremes. Immunoglobulin A (IgA, also referred to as sIgA) is an antibody that plays a critical role in immune function in the mucous membranes. More IgA is produced in mucosal linings than all other types of antibody combined. Examples are EMA, ACA ELISA test kits and for diagnostic detection the IgA of Anti-Beta-2 Glycoprotein 1; β2-Glycoprotein 1 Antibodies; Beta 2GP1 Ab, Beta-2 Glycoprotein 1 Antibodies IgG, IgM, and IgAs.
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Conjugation
Anti-FITC Antibody
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Gene target
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Gene symbol
FCAR
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Short name
CD89 (CD89 Antigen, FCAR, Immunoglobulin alpha Fc Receptor, IgA Fc Receptor) (FITC)
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Technique
antigen, FITC, IgA, FC, antigenes, Fluorescein, IgAs
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Host
Mouse
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Isotype
IgG1, IgA
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Label
FITC
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Alternative name
CD89 (CD89 protein, fragment c fragment on Immunoglobulin A, receptor to measure, Immunoglobulin a fragment c Receptor, Immunoglobulin A fragment c Receptor) (fluorecein)
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Alternative technique
antigenes, fluorescine, immunoglobulin-a
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Alternative to gene target
Fc fragment of IgA, receptor for, CD89, FCAR and IDBG-69662 and ENSG00000186431 and 2204, IgA binding, Extracellular, FCAR and IDBG-641994 and ENSBTAG00000021647 and 503555
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