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ALK (Anaplastic Lymphoma Kinase)/CD246

  • Catalog number
    MBS439976
  • Product name
    ALK (Anaplastic Lymphoma Kinase)/CD246
  • Size
    0.02 mg (With BSA & Azide at 0.2mg/mL)
  • Products type
    Antibody
  • Products short name
    [ALK (Anaplastic Lymphoma Kinase)/CD246]
  • Products name syn
    [ALK Tyrosine Kinase Receptor; ALK/NPM1 fusion gene; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; mutant anaplastic lymphoma kinase; NBLST3; Tcrz; TFG/ALK]
  • Other names
    [ALK tyrosine kinase receptor isoform 1; ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; ALK receptor tyrosine kinase; Anaplastic lymphoma kinase; CD_antigen: CD246]
  • Products gene name
    [ALK]
  • Products gene name syn
    [CD246]
  • Other gene names
    [ALK; ALK; CD246; NBLST3]
  • Clonality
    Monoclonal
  • Isotype
    IgG2b, kappa
  • Clone
    [ALK/1504]
  • Host
    Mouse
  • Reactivity
    Human. Others not known.
  • Specificity
    The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene, NPM-ALK, created by the t(2; 5)(p23; q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
  • Form
    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  • Storage stability
    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • Tested application
    Immunohistochemistry (IHC) Formalin
  • Alternative to gene target
    • [ "anaplastic lymphoma receptor tyrosine kinase", "CD246 and NBLST3", "ALK and IDBG-42084 and ENSG00000171094 and 238", "transferase activity", "Plasma membranes", "Alk and IDBG-197259 and ENSMUSG00000055471 and 11682", "ALK and IDBG-636042 and ENSBTAG00000007379 and 536642" ]
  • Gene target
    ALK Anaplastic Lymphoma Kinase /CD246
    • Gene info
    Locus Specific Databases:LRG_488
    Gene info
    Gene info
    Locus Specific Databases:LOVD - Center for Medical Genetics, Ghent, Belgium
    Gene info
    Locus Specific Databases:LRG_712
  • Gene symbol
    ALK, ENPP7, TGFBR1, BMPR2
  • isotype filter
    • IgG2b
    • kappa
  • Short name
    ALK (Anaplastic Lymphoma Kinase)/CD246