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Reindeer papillomavirus Protein E5 (E5) -Yeast

  • Catalog number
    bs-5221R-Cy7
  • Product name
    BRCA1 (Ser1189) Antibody, Cy7 Conjugated
  • Size
    0.1ml
  • Short name
    Anti-BRCA1 Ser1189
  • Long name
    BRCA1 (Ser1189) Polyclonal Antibody, Cy7 Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    Cy7
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    BRCA1 Ser1189
  • Specificity
    This is a highly specific antibody against BRCA1 Ser1189.
  • Modification
    Phosphorylation
  • Modification site
    Ser1189
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1189
  • Gene ID number
    672
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    743nm/767nm
  • Synonyms
    BRCA1 phospho Ser1189; BRCA1 phospho S1189; p-BRCA1 phospho S1189; BRCA 1; BRCA1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1.
  • Alternative to gene target
    • [ "breast cancer 1, early onset", "BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53", "BRCA1 and IDBG-52172 and ENSG00000012048 and 672", "androgen receptor binding", "nuclei", "Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189", "BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120" ]
  • Gene target
    BRCA1 Ser1189 Conjugated
    • Gene info
    Locus Specific Databases:Breast CancerFanconi Anaemia Mutation DatabaseBRCA1 database at LOVD-ChinaGlobal Variome shared LOVDLOVD - Leiden Open Variation DatabaseLRG_292
    Gene info
  • Gene symbol
    BRCA1, BRCA1P1
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    Cy7
  • label filter
    • Cy7
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Alternative technique
    antibodies