- Catalog numberbs-6473R-A647
- Product nameMUSK Antibody, ALEXA FLUOR 647
- Size100ul
- PriceAsk For Price
- Short nameAnti-MUSK
- Long nameMUSK Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
- Also known asAnti-MUSK PAb ALEXA FLUOR 647
- CategoryConjugated Primary Antibodies
- Conjugated withALEXA FLUOR® 647
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenMUSK
- SpecificityThis is a highly specific antibody against MUSK.
- ModificationUnmodified
- Modification SiteNone
- ClonalityPolyclonal
- ClonePolyclonal antibody
- IsotypeImmunoglobulin G (IgG)
- Concentration1ug per 1ul
- Immunogen range260-310/869
- Subcellular locationExtracellular
- SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MUSK
- Gene ID Number4593
- Swiss ProtO15146
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman, Mouse, Rat
- Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the antigenReceptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).
- PurificationPurified by Protein A.
- Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
- Excitation emission650nm/665nm
- SynonymsCMS9; FADS; Muscle, skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor
- Gene targetMUSK
- Identity:HGNC:7525
- Gene:MUSK
- Long gene name:muscle associated receptor tyrosine kinase
- Synonyms gene name:muscle, skeletal, receptor tyrosine kinase
- Discovery year:1997-04-10
- Entrez gene record:4593
- Pubmed identification:7546737
- Classification:Immunoglobulin like domain containing, I-set domain containing, Receptor tyrosine kinases
- VEGA ID:OTTHUMG00000020485
- Gene symbolMUSK
- isotype filter
- Immunoglobulin G IgG
- LabelALEXA FLUOR 647
- label filter
- ALEXA FLUOR 647
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies