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Anti-HUMAN CD279

  • Catalog number
    MBS223817
  • Product name
    Anti-HUMAN CD279
  • Size
    100ug
  • Price
    Ask For Price
  • Contact us
    Anti-HUMAN CD279
  • Alternative name1
    Anti-RABBIT ANTI HUMAN CD279
  • Alternative name2
    RABBIT ANTI HUMAN CD279
  • Alternative name3
    Lapin ANTI Homo sapiens CD279
  • Alternative name4
    CD279
  • Alternative name5
    N/A
  • Other names
    programmed cell death protein 1; Programmed cell death protein 1; programmed cell death protein 1; protein PD-1; programmed cell death 1; N/A
  • Gene name
    CD279
  • Gene name synonims
    N/A
  • Other gene names
    PDCD1; PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; PD1; Protein PD-1; hPD-1
  • Category
    Antibodies
  • Clonality
    Polyclonal
  • Immunoglobulin isotype
    Polyclonal IgG
  • Clone
    Polyclonal antibody
  • Host organism
    Rabbit
  • Species reactivity
    Human
  • Specificity and cross reactivity
    CD279 This item detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is a single-pass type 1 membrane protein belonging to the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. _x000D__x000D_Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
  • Purification method
    N/A
  • Form Appearance
    Purified (Purified IgG - liquid)
  • Concentration
    IgG concentration 1.0mg/ml
  • Storage and shipping
    Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
  • Tested for
    Immunohistology - Paraffin (IHC), Western Blot (WB)
  • Description
    productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
  • Advisory
    In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Gene target
    CD279
    • Gene info
  • Gene symbol
    PDCD1
  • Short name
    Anti- CD279
  • technique filter
    • anti-Human
    • anti-
    • anti
  • Technique
    anti-Human, anti-, anti, antibody to, antibodies, antibodies against human proteins
  • Alternative technique
    antibodies