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NFkB Activating Kinase (Nuclear Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1) Antibody

  • Catalog number
    GEN604330
  • Product name
    NFkB Activating Kinase (Nuclear Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1) Antibody
  • Size
    100ug
  • Also known as
    NFkB Activating Kinase
  • Other names
    NEDD4 family-interacting protein 1; NEDD4 family-interacting protein 1; NEDD4 family-interacting protein 1; Nedd4 WW domain-binding protein 5; putative MAPK-activating protein PM13; breast cancer-associated protein SGA-1M; putative NFKB and MAPK-activating protein; putative NF-kappa-B-activating protein 164; Nedd4 family interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein
  • Category
    Antibodies
  • Subcategory
    Mnoclonal antibodies
  • Gene name
    NDFIP1; NDFIP1; N4WBP5; N4WBP5
  • Gene name synonims
    NDFIP1; NDFIP1; N4WBP5; N4WBP5
  • Other gene names
    NDFIP1; NDFIP1; N4WBP5; N4WBP5
  • Clonality
    Monoclonal
  • Immunoglobulin isotype
    IgG1
  • Clone
    4H209
  • Host organism
    Mouse (Mus musculus)
  • Source organism
    Human (Homo sapiens)
  • Species reactivity
    Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
  • Specificity and cross reactivity
    NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) (6) and MAP kinase kinase kinase-1 (MEKK1) (7), respectively. Recently, a new IKK family member, TBK1 (TANK-binding kinase) has been identified (8). TANK (TRAF-associated NF-kB activator) interacts with TBK1 and activates NF-kB in a kinase dependent manner. ; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
  • Purification method
    Affinity Purified by Protein G affinity chromatography.
  • Form Appearance
    Supplied as a liquid in PBS, 0.02% sodium azide.
  • Concentration
    N/A
  • Storage and shipping
    Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage, For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
  • Tested applications
    Western Blot (WB)
  • Alternative to gene target
    • [ "TANK-binding kinase 1", "TBK1 and IDBG-44993 and ENSG00000183735 and 29110", "transferase activity", "Cytoplasm", "Tbk1 and IDBG-192882 and ENSMUSG00000020115 and 56480", "TBK1 and IDBG-634420 and ENSBTAG00000017401 and 533141" ]
  • Gene target
    NFkB Activating Kinase Factor kappa B TANK-Binding Kinase 1 NAK TBK1
    • Gene info
    Locus Specific Databases:LRG_1306
    Gene info
    • Identity:HGNC:40575
    • Gene:TANK-AS1
    • Long gene name:TANK antisense RNA 1
    • Discovery year:2020-03-27
    • Entrez gene record:105373719
    • Classification:Antisense RNAs
    Gene info
    Gene info
  • Gene symbol
    TBK1, TANK-AS1, TANK, NR4A1
  • Short name
    NFkB Activating Kinase ( Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1) Antibody
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies